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Literature DB >> 11796636

Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.

Antonella Torosantucci¹, Paola Chiani, Flavia De Bernardis, Antonio Cassone, Jose Antonio Calera, Richard Calderone.

Abstract

We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis.

Entities: Disease Species

Mesh：

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Year: 2002 PMID： 11796636 PMCID： PMC127696 DOI： 10.1128/IAI.70.2.985-987.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

19 in total

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Authors: J A Calera; G H Choi; R A Calderone
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