| Literature DB >> 11796382 |
Sung Wook Park1, Jeoung Soon We, Gye Won Kim, Seong Hak Choi, Haeng Soon Park.
Abstract
The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme's preference for substrates. Our results showed a decreasing order of imipenem (6.24), meropenem (2.41), and DA-1131 (1.39). The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven.Entities:
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Year: 2002 PMID： 11796382 PMCID： PMC127065 DOI： 10.1128/AAC.46.2.575-577.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191