Literature DB >> 11796066

An aldol-based approach to the synthesis of the antibiotic anisomycin.

Alison N Hulme1, Edward M Rosser.   

Abstract

[reaction: see text] A new approach to the synthesis of the antibiotic anisomycin is reported that relies upon a key aldol disconnection. The glycolate aldol coupling proceeds in 75% yield and with >95% diastereoselectivity, which allows the 13-step synthesis to proceed in 35% overall yield.

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Year:  2002        PMID： 11796066     DOI： 10.1021/ol017016u

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases.

Authors:  Lukasz Berlicki; Marta Bochno; Agnieszka Grabowiecka; Arkadiusz Białas; Paulina Kosikowska; Paweł Kafarski
Journal:  Amino Acids       Date:  2011-05-11       Impact factor: 3.520

2.  Acyltransferase AniI, a Tailoring Enzyme with Broad Substrate Tolerance for High-Level Production of Anisomycin.

Authors:  Qing Wang; Lingxin Kong; Xiaoqing Zheng; Jufang Shen; Junbo Wang; Dashan Zhang; Yongjian Qiao; Jinjin Wang; Zixin Deng; Delin You
Journal:  Appl Environ Microbiol       Date:  2021-06-25       Impact factor: 4.792
  2 in total

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