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Literature DB >> 11796049

Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris.

Karen Schmidt¹, Wolfgang Günther, Stefka Stoyanova, Barbara Schubert, Zengzhi Li, Matthias Hamburger.

Abstract

[structure: see text] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 microM concentrations.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 11796049 DOI： 10.1021/ol016920j

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

10 in total

Review 1. Neurotrophic natural products: chemistry and biology.

Authors: Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal: Angew Chem Int Ed Engl Date: 2013-12-18 Impact factor: 15.336

2. Biomimetic conversion of (-)-fusoxypyridone and (-)-oxysporidinone to (-)-sambutoxin: further evidence for the structure of the tricyclic pyridone alkaloid, (-)-fusoxypyridone.

Authors: E M Kithsiri Wijeratne; A A Leslie Gunatilaka
Journal: Bioorg Med Chem Lett Date: 2011-03-16 Impact factor: 2.823

Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris.

Review 1. Neurotrophic natural products: chemistry and biology.

2. Biomimetic conversion of (-)-fusoxypyridone and (-)-oxysporidinone to (-)-sambutoxin: further evidence for the structure of the tricyclic pyridone alkaloid, (-)-fusoxypyridone.

3. Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action.

4. Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris.

Review 5. Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory?

Review 6. Secondary Metabolites and Their Bioactivities Produced by Paecilomyces.

7. Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches.

8. Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea.

Review 9. Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis.

Review 10. Pyridine alkaloids with activity in the central nervous system.