Literature DB >> 11796040

Synthesis and application of a chain-terminating dinucleotide mRNA cap analog.

Zheng-Hong Peng1, Vivek Sharma, Scott F Singleton, Paul D Gershon.   

Abstract

[structure: see text] We describe the synthesis of a chain-terminating mRNA cap dinucleotide and its use in the in vitro transcription of homogeneously capped RNA. Computer modeling strongly indicates that RNA capped with the new compound will be a substrate for cap-dependent translation.

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Year:  2002        PMID： 11796040     DOI： 10.1021/ol0167715

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  15 in total

1.  Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency.

Authors:  Ewa Grudzien; Janusz Stepinski; Marzena Jankowska-Anyszka; Ryszard Stolarski; Edward Darzynkiewicz; Robert E Rhoads
Journal:  RNA       Date:  2004-09       Impact factor: 4.942

2.  Intracellular pH sensing is altered by plasma membrane PIP aquaporin co-expression.

Authors:  Jorge Bellati; Karina Alleva; Gabriela Soto; Victoria Vitali; Cintia Jozefkowicz; Gabriela Amodeo
Journal:  Plant Mol Biol       Date:  2010-07-01       Impact factor: 4.076

3.  Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

Authors:  Malwina Strenkowska; Joanna Kowalska; Maciej Lukaszewicz; Joanna Zuberek; Wei Su; Robert E Rhoads; Edward Darzynkiewicz; Jacek Jemielity
Journal:  New J Chem       Date:  2010-01-01       Impact factor: 3.591

Review 4.  mRNA-based therapeutics: powerful and versatile tools to combat diseases.

Authors:  Shugang Qin; Xiaoshan Tang; Yuting Chen; Kepan Chen; Na Fan; Wen Xiao; Qian Zheng; Guohong Li; Yuqing Teng; Min Wu; Xiangrong Song
Journal:  Signal Transduct Target Ther       Date:  2022-05-21

5.  Synthesis and application of 2'-fluoro-substituted cap analogs.

Authors:  Anilkumar R Kore; Muthian Shanmugasundaram; Irudaya Charles; Angie M Cheng; Timothy J Barta
Journal:  Bioorg Med Chem Lett       Date:  2007-08-16       Impact factor: 2.823

6.  Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells.

Authors:  Ewa Grudzien-Nogalska; Jacek Jemielity; Joanna Kowalska; Edward Darzynkiewicz; Robert E Rhoads
Journal:  RNA       Date:  2007-08-24       Impact factor: 4.942

7.  Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

Authors:  Joanna Kowalska; Magdalena Lewdorowicz; Joanna Zuberek; Ewa Grudzien-Nogalska; Elzbieta Bojarska; Janusz Stepinski; Robert E Rhoads; Edward Darzynkiewicz; Richard E Davis; Jacek Jemielity
Journal:  RNA       Date:  2008-04-22       Impact factor: 4.942

8.  Novel "anti-reverse" cap analogs with superior translational properties.

Authors:  Jacek Jemielity; Tolvert Fowler; Joanna Zuberek; Janusz Stepinski; Magdalena Lewdorowicz; Anna Niedzwiecka; Ryszard Stolarski; Edward Darzynkiewicz; Robert E Rhoads
Journal:  RNA       Date:  2003-09       Impact factor: 4.942

9.  Chemo-Enzymatic Modification of the 5' Cap Maintains Translation and Increases Immunogenic Properties of mRNA.

Authors:  Melissa van Dülmen; Nils Muthmann; Andrea Rentmeister
Journal:  Angew Chem Int Ed Engl       Date:  2021-05-06       Impact factor: 15.336

Review 10.  Synthetic mRNA capping.

Authors:  Fabian Muttach; Nils Muthmann; Andrea Rentmeister
Journal:  Beilstein J Org Chem       Date:  2017-12-20       Impact factor: 2.883
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