| Literature DB >> 11795280 |
H Ishii1, M Yoshida, K A Hajjar, A Tanaka, Y Yasukochi, K Shimokado, F Numano.
Abstract
Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co-receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generation on the surface of vascular endothelium. In this review, we overviewed the effect of glucose and insulin on plasmin generation in endothelial cells and its potential modulation by recombinant annexin II (rAN II) based on our data.Entities:
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Year: 2001 PMID： 11795280 DOI： 10.1111/j.1749-6632.2001.tb03953.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691