Literature DB >> 11794524

Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand.

H O Kim1.   

Abstract

2-(1-Hexynyl), 2-((E)-1-hexenyl) and 2-(n-hexyl)-N6-methyladenines were synthesized, starting from 2-amino-6-chloropurine using palladium-catalyzed coupling as a key step as potential adenosine receptor ligand.

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Year:  2001        PMID: 11794524     DOI: 10.1007/bf02975154

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN: 0253-6269            Impact factor:   4.946


  1 in total

1.  2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.

Authors:  Hak Sung Kim; Michihiro Ohno; Bin Xu; Hea Ok Kim; Yongseok Choi; Xiao D Ji; Savitri Maddileti; Victor E Marquez; T Kendall Harden; Kenneth A Jacobson
Journal:  J Med Chem       Date:  2003-11-06       Impact factor: 7.446

  1 in total

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