Literature DB >> 11793719

A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci.

N J Camp1, A Gutin, V Abkevich, J M Farnham, L Cannon-Albright, A Thomas.   

Abstract

We describe an alternative nonparametric linkage (NPL) statistic to that of Kruglyak et al. [Am. J. Hum. Genet. 58:1347-63, 1996] that can be used with qualitative phenotypes, and is easily extended for use with quantitative phenotypes. We analyzed the Genetic Analysis Workshop 12 simulated isolated population data, replicate 1, using two phenotypes; affected status (AFF) a dichotomous phenotype and quantitative trait Q5, which was chosen since it was the most strongly associated with AFF. One false positive significant NPL score was observed for the AFF phenotype. For Q5 a single region on chromosome 1 reached genome-wide significance. The peak of this signal was for marker D01G137 at 135.1 cM with a quantitative trait locus (QTL)-NPL score of 4.19. The nearest marker to the true location of the major gene (MG5 at 137.1 cM) was D01G139 at position 135.8 cM, where the QTL-NPL score was still high at 4.08.

Mesh：

Year:  2001        PMID： 11793719     DOI： 10.1002/gepi.2001.21.s1.s461

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  6 in total

1.  A major predisposition locus for severe obesity, at 4p15-p14.

Authors:  Steven Stone; Victor Abkevich; Steven C Hunt; Alexander Gutin; Deanna L Russell; Chris D Neff; Robyn Riley; Georges C Frech; Charles H Hensel; Srikanth Jammulapati; Jennifer Potter; David Sexton; Thanh Tran; Drew Gibbs; Diana Iliev; Richard Gress; Brian Bloomquist; John Amatruda; Peter M M Rae; Ted D Adams; Mark H Skolnick; Donna Shattuck
Journal:  Am J Hum Genet       Date:  2002-04-15       Impact factor: 11.025

2.  Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.

Authors:  N J Camp; S L Neuhausen; J Tiobech; A Polloi; H Coon; M Myles-Worsley
Journal:  Am J Hum Genet       Date:  2001-10-19       Impact factor: 11.025

3.  Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information.

Authors:  Tasha E Fingerlin; Michael Boehnke; Gonçalo R Abecasis
Journal:  Am J Hum Genet       Date:  2004-02-02       Impact factor: 11.025

4.  Linkage analysis of Tourette syndrome in a large Utah pedigree.

Authors:  Stacey Knight; Hilary Coon; Michael Johnson; Mark F Leppert; Nicola J Camp; William M McMahon
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2010-03-05       Impact factor: 3.568

5.  Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees.

Authors:  Hilary Coon; Michele E Villalobos; Reid J Robison; Nicola J Camp; Dale S Cannon; Kristina Allen-Brady; Judith S Miller; William M McMahon
Journal:  Mol Autism       Date:  2010-04-08       Impact factor: 7.509

6.  Genome-wide analysis of high-risk primary brain cancer pedigrees identifies PDXDC1 as a candidate brain cancer predisposition gene.

Authors:  Lisa A Cannon-Albright; James M Farnham; Jeffrey Stevens; Craig C Teerlink; Cheryl A Palmer; Kerry Rowe; Melissa H Cessna; Deborah T Blumenthal
Journal:  Neuro Oncol       Date:  2021-02-25       Impact factor: 12.300
  6 in total

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