Literature DB >> 1179220

Myasthenia gravis: passive transfer from man to mouse.

K V Toyka, D B Brachman, A Pestronk, I Kao.   

Abstract

Daily injections into mice of an ammonium sulfate-precipitated immunoglobulin fraction of serum from patients with myasthenia gravis were carried out for up to 14 days. The mice showed reduced amplitudes of miniature endplate potentials and reduced numbers of acetylcholine receptors at the neuromuscular junctions. Some mice showed typical decremental responses on repetitive nerve stimulation, with reversal by neostigmine. This represents the first evidence of a circulating factor in the serum of patients with myasthenia gravis which on passive transfer reproduces features of the disease in experimental animals.

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Year:  1975        PMID： 1179220     DOI： 10.1126/science.1179220

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  92 in total

1.  Treatment of passively transferred experimental autoimmune myasthenia gravis using papain.

Authors:  K Poulas; T Tsouloufis; S J Tzartos
Journal:  Clin Exp Immunol       Date:  2000-05       Impact factor: 4.330

2.  Autonomic "myasthenia": the case for an autoimmune pathogenesis.

Authors:  Daniel B Drachman
Journal:  J Clin Invest       Date:  2003-03       Impact factor: 14.808

Review 3.  Intrathymic expression of neuromuscular acetylcholine receptors and the immunpathogenesis of myasthenia gravis.

Authors:  Arnold I Levinson; Yi Zheng; Glen Gaulton; Decheng Song; Jonni Moore; C Hank Pletcher
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

4.  Immunoglobulin heavy chain gene associations in myasthenia gravis: new evidence for disease heterogeneity.

Authors:  A Demaine; N Willcox; M Janer; K Welsh; J Newsom-Davis
Journal:  J Neurol       Date:  1992-01       Impact factor: 4.849

5.  The problems and promises of research into human immunology and autoimmune disease.

Authors:  Bart O Roep; Jane Buckner; Stephen Sawcer; Rene Toes; Frauke Zipp
Journal:  Nat Med       Date:  2012-01-06       Impact factor: 53.440

Review 6.  Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies.

Authors:  Emilia H Moscato; Ankit Jain; Xiaoyu Peng; Ethan G Hughes; Josep Dalmau; Rita J Balice-Gordon
Journal:  Eur J Neurosci       Date:  2010-07-14       Impact factor: 3.386

7.  Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Authors:  C Hammer; B Stepniak; A Schneider; S Papiol; M Tantra; M Begemann; A-L Sirén; L A Pardo; S Sperling; S Mohd Jofrry; A Gurvich; N Jensen; K Ostmeier; F Lühder; C Probst; H Martens; M Gillis; G Saher; F Assogna; G Spalletta; W Stöcker; T F Schulz; K-A Nave; H Ehrenreich
Journal:  Mol Psychiatry       Date:  2013-09-03       Impact factor: 15.992

Review 8.  [Plasma exchange as a therapeutic option in neurological disorders].

Authors:  H C Lehmann; H P Hartung; G R Hetzel; B C Kieseier
Journal:  Nervenarzt       Date:  2007-02       Impact factor: 1.214

Review 9.  Myasthenia gravis--current concepts.

Authors:  C Herrmann; J M Lindstrom; J C Keesey; D G Mulder
Journal:  West J Med       Date:  1985-06

10.  Cross-reactivity of autoantibodies from patients with epidermolysis bullosa acquisita with murine collagen VII.

Authors:  Kinga Csorba; Alina Sesarman; Eva Oswald; Vasile Feldrihan; Anja Fritsch; Takashi Hashimoto; Cassian Sitaru
Journal:  Cell Mol Life Sci       Date:  2010-01-20       Impact factor: 9.261
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