H Kokki1, H Tuomilehto, M Karvinen. 1. Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland. hannu.kokki@kuh.fi
Abstract
OBJECTIVE: The pharmacokinetics of ketoprofen following intramuscular injection or oral tablet was determined in children aged 10-69 months. METHODS: Ten children received a single intramuscular injection of 1 mg kg(-1) ketoprofen. Six children, weight 12-17 kg, received a 12.5-mgketoprofen tablet and four children, weight 18-23 kg, received a 25-mg tablet. Venous blood samples were collected at 15 min and 30 min and 1, 2, 4, 6 and 8 h following drug dosing. Plasma ketoprofen levels were measured using a validated high-performance liquid chromatography method. RESULTS: The maximal plasma concentration of ketoprofen ranged between 3.6 microg ml(-1) and 7.4 microg ml(-1) in the intramuscular group and, following a dose normalisation, between 2.8 microg ml(-1) and 8.2 microg ml(-1) in the tablet group (dose normalised for 1 mg kg(-1)). The rate and extent of absorption of ketoprofen were comparable after intramuscular and oral administration. The relative bioavailability of oral ketoprofen was about 100% of the intramuscular administration. The extrapolated area under the plasma concentration-time curve (AUC0-infinity) ranged between 8.8 microg ml(-1) h and 14.6 microg ml(-1) h in the intramuscular group and between 8.7 microg ml(-1) h and 14.1 microg ml(-1) h in the tablet group (dose-normalised AUC0-infinity). The terminal half-life was comparable in both study groups, ranging between 0.8 h and 2.2 h in the intramuscular group and between 0.9 h and 2.1 h in the tablet group. CONCLUSION: According to the pharmacokinetic properties determined in this study, there is no justification for using intramuscular administration in awake children.
RCT Entities:
OBJECTIVE: The pharmacokinetics of ketoprofen following intramuscular injection or oral tablet was determined in children aged 10-69 months. METHODS: Ten children received a single intramuscular injection of 1 mg kg(-1) ketoprofen. Six children, weight 12-17 kg, received a 12.5-mg ketoprofen tablet and four children, weight 18-23 kg, received a 25-mg tablet. Venous blood samples were collected at 15 min and 30 min and 1, 2, 4, 6 and 8 h following drug dosing. Plasma ketoprofen levels were measured using a validated high-performance liquid chromatography method. RESULTS: The maximal plasma concentration of ketoprofen ranged between 3.6 microg ml(-1) and 7.4 microg ml(-1) in the intramuscular group and, following a dose normalisation, between 2.8 microg ml(-1) and 8.2 microg ml(-1) in the tablet group (dose normalised for 1 mg kg(-1)). The rate and extent of absorption of ketoprofen were comparable after intramuscular and oral administration. The relative bioavailability of oral ketoprofen was about 100% of the intramuscular administration. The extrapolated area under the plasma concentration-time curve (AUC0-infinity) ranged between 8.8 microg ml(-1) h and 14.6 microg ml(-1) h in the intramuscular group and between 8.7 microg ml(-1) h and 14.1 microg ml(-1) h in the tablet group (dose-normalised AUC0-infinity). The terminal half-life was comparable in both study groups, ranging between 0.8 h and 2.2 h in the intramuscular group and between 0.9 h and 2.1 h in the tablet group. CONCLUSION: According to the pharmacokinetic properties determined in this study, there is no justification for using intramuscular administration in awake children.
Authors: Victoria C Ziesenitz; Tatjana Welzel; Madelé van Dyk; Patrick Saur; Matthias Gorenflo; Johannes N van den Anker Journal: Paediatr Drugs Date: 2022-09-02 Impact factor: 3.930
Authors: S Celebi; M Hacimustafaoglu; D Aygun; E S Arisoy; Y Karali; S Akgoz; A N Citak Kurt; M Seringec Journal: Indian J Pediatr Date: 2009-01-05 Impact factor: 1.967
Authors: Hannu Kokki; Ilpo Rasanen; Matti Reinikainen; Pekka Suhonen; Kari Vanamo; Ilkka Ojanperä Journal: Clin Pharmacokinet Date: 2004 Impact factor: 6.447