| Literature DB >> 11790552 |
Margaret C Frame1, Valerie G Brunton.
Abstract
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.Entities:
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Year: 2002 PMID： 11790552 DOI： 10.1016/s0959-437x(01)00261-1
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578