Literature DB >> 11790550

TGF-beta signaling: positive and negative effects on tumorigenesis.

Lalage M Wakefield1, Anita B Roberts.   

Abstract

TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.

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Year:  2002        PMID： 11790550     DOI： 10.1016/s0959-437x(01)00259-3

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  267 in total

1.  Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Authors:  Juliet A Williams; Oivin M Guicherit; Beatrice I Zaharian; Yin Xu; Ling Chai; Hynek Wichterle; Charlene Kon; Christine Gatchalian; Jeffery A Porter; Lee L Rubin; Frank Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-04       Impact factor: 11.205

2.  Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.

Authors:  Arun R Pandiri; Robert C Sills; Mark J Hoenerhoff; Shyamal D Peddada; Thai-Vu T Ton; Hue-Hua L Hong; Gordon P Flake; David E Malarkey; Greg R Olson; Igor P Pogribny; Nigel J Walker; Mary D Boudreau
Journal:  Toxicol Pathol       Date:  2011-09-21       Impact factor: 1.902

3.  Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription.

Authors:  Xia Lin; Yao-Yun Liang; Baohua Sun; Min Liang; Yujiang Shi; F Charles Brunicardi; Yang Shi; Xin-Hua Feng
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

4.  TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses.

Authors:  Li Yu; Mindy C Hébert; Ying E Zhang
Journal:  EMBO J       Date:  2002-07-15       Impact factor: 11.598

Review 5.  TGF-beta antagonists: why suppress a tumor suppressor?

Authors:  Rosemary J Akhurst
Journal:  J Clin Invest       Date:  2002-06       Impact factor: 14.808

Review 6.  The two faces of transforming growth factor beta in carcinogenesis.

Authors:  Anita B Roberts; Lalage M Wakefield
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-14       Impact factor: 11.205

7.  Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.

Authors:  John M Lamar; Vandana Iyer; C Michael DiPersio
Journal:  J Invest Dermatol       Date:  2007-08-30       Impact factor: 8.551

8.  alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.

Authors:  M Teresa Romero-Avila; C Fabián Flores-Jasso; J Adolfo García-Sáinz
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

9.  15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

Authors:  Min Yan; Ronald M Rerko; Petra Platzer; Dawn Dawson; Joseph Willis; Min Tong; Earl Lawrence; James Lutterbaugh; Shilong Lu; James K V Willson; Guangbin Luo; Jack Hensold; Hsin-Hsiung Tai; Keith Wilson; Sanford D Markowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-01       Impact factor: 11.205

Review 10.  Matrix remodeling in chronic lung diseases.

Authors:  Bon-Hee Gu; Matthew C Madison; David Corry; Farrah Kheradmand
Journal:  Matrix Biol       Date:  2018-03-17       Impact factor: 11.583
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