Optimal treatment of nevirapine-associated hepatotoxicity remains uncertain.

The cases of 2 patients with nevirapine-associated hepatotoxicity in conjunction with rash and eosinophilia are reported here. Both patients' conditions improved following withdrawal of nevirapine. Previous case reports have described a variety of interventions other than drug withdrawal that might have contributed to resolution of drug-induced hepatitis. Until a better understanding of the clinical spectrum and pathophysiology of nevirapine-associated hepatotoxicity is realized, treatment will remain largely empiric.