| Literature DB >> 11787732 |
C W Daniel1, S Robinson, G B Silberstein.
Abstract
The transforming growth factors beta (TGF-beta) are multifunctional regulators with diverse effects on a variety of developmental processes and differentiated functions. In the mammary gland, a considerable amount of evidence has accumulated indicating that TGF-beta plays a critical role during several phases of the mammary cycle. TGF-beta regulates growth and patterning of the mammary ductal tree in the virgin mouse. During pregnancy, TGF-beta is required for alveolar development and functional differentiation, while at the same time inhibiting secretion of milk proteins. At parturition this inhibition is lifted, permitting initiation of lactation.Entities:
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Year: 2001 PMID： 11787732 DOI： 10.1007/978-1-4615-1371-1_7
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622