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Literature DB >> 11786980

New therapeutic strategies for hepatitis C.

Adrian M Di Bisceglie¹, John McHutchison, Charles M Rice.

Abstract

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Year: 2002 PMID： 11786980 DOI： 10.1053/jhep.2002.30531

Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425

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18 in total

1. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Authors: Lieven J Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung K Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Raymond F Schinazi
Journal: Antimicrob Agents Chemother Date: 2003-01 Impact factor: 5.191

2. Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C.

Authors: Kaori Mochizuki; Tatehiro Kagawa; Shinji Takashimizu; Kazuya Kawazoe; Sei-Ichiro Kojima; Naruhiko Nagata; Atsushi Nakano; Yasuhiro Nishizaki; Koichi Shiraishi; Masaru Itakura; Norihito Watanabe; Tetsuya Mine; Shohei Matsuzaki
Journal: World J Gastroenterol Date: 2004-03-01 Impact factor: 5.742

3. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.

Authors: Junxing Shi; Longhu Zhou; Hongwang Zhang; Tamara R McBrayer; Mervi A Detorio; Melissa Johns; Leda Bassit; Megan H Powdrill; Tony Whitaker; Steven J Coats; Matthias Götte; Raymond F Schinazi
Journal: Bioorg Med Chem Lett Date: 2011-09-29 Impact factor: 2.823

Review 4. Hepatitis infection in the treatment of opioid dependence and abuse.

Authors: Thomas F Kresina; Diana Sylvestre; Leonard Seeff; Alain H Litwin; Kenneth Hoffman; Robert Lubran; H Westley Clark
Journal: Subst Abuse Date: 2008-04-28

5. The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

Authors: Eisuke Murakami; Congrong Niu; Haiying Bao; Holly M Micolochick Steuer; Tony Whitaker; Tammy Nachman; Michael A Sofia; Peiyuan Wang; Michael J Otto; Phillip A Furman
Journal: Antimicrob Agents Chemother Date: 2007-11-12 Impact factor: 5.191

6. A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro.

Authors: Guofeng Cheng; Ana Montero; Pablo Gastaminza; Christina Whitten-Bauer; Stefan F Wieland; Masanori Isogawa; Brenda Fredericksen; Suganya Selvarajah; Philippe A Gallay; M Reza Ghadiri; Francis V Chisari
Journal: Proc Natl Acad Sci U S A Date: 2008-02-19 Impact factor: 11.205

New therapeutic strategies for hepatitis C.

1. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

2. Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C.

3. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.

Review 4. Hepatitis infection in the treatment of opioid dependence and abuse.

5. The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

6. A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro.

7. Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice.

8. Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia.

9. Characterization of resistance to the protease inhibitor GS-9451 in hepatitis C virus-infected patients.

10. Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A.