| Literature DB >> 11786910 |
Ville Wallenius1, Kristina Wallenius, Bo Ahrén, Mats Rudling, Hans Carlsten, Suzanne L Dickson, Claes Ohlsson, John-Olov Jansson.
Abstract
The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11786910 DOI： 10.1038/nm0102-75
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440