OBJECTIVES: There has been uncertainty in the adult body composition literature about whether fat mass (FM) or fat free mass is a better predictor of bone mineral content and bone mineral density. This issue has recently also been raised in the pediatric literature. Based on suggested skeletal muscle-bone relationships, this study tested the hypothesis that in children and adolescents lean tissue mass (LTM) is a better predictor of total bone mineral content (TBMC) than is FM. RESEARCH METHODS AND PROCEDURES: Subjects were 133 Italian children and adolescents, 5 to 17 years of age, undergoing a routine medical screen. FM (kilograms), LTM (kilograms), and TBMC (kilograms) were measured by DXA. Multiple regression analyses tested the independent association of FM and LTM with bone mineral content. RESULTS: Regression analyses, adjusting for pubertal status and other covariates, showed that FM and LTM were independently associated with TBMC. These associations were similar for boys and girls. TBMC was more strongly associated with LTM than FM. DISCUSSION: These observations support the hypothesis that in children and adolescents a close association exists between LTM, a measure of skeletal muscle, and skeletal characteristics.
OBJECTIVES: There has been uncertainty in the adult body composition literature about whether fat mass (FM) or fat free mass is a better predictor of bone mineral content and bone mineral density. This issue has recently also been raised in the pediatric literature. Based on suggested skeletal muscle-bone relationships, this study tested the hypothesis that in children and adolescents lean tissue mass (LTM) is a better predictor of total bone mineral content (TBMC) than is FM. RESEARCH METHODS AND PROCEDURES: Subjects were 133 Italian children and adolescents, 5 to 17 years of age, undergoing a routine medical screen. FM (kilograms), LTM (kilograms), and TBMC (kilograms) were measured by DXA. Multiple regression analyses tested the independent association of FM and LTM with bone mineral content. RESULTS: Regression analyses, adjusting for pubertal status and other covariates, showed that FM and LTM were independently associated with TBMC. These associations were similar for boys and girls. TBMC was more strongly associated with LTM than FM. DISCUSSION: These observations support the hypothesis that in children and adolescents a close association exists between LTM, a measure of skeletal muscle, and skeletal characteristics.
Authors: Germán Vicente-Rodríguez; Alejandro Urzanqui; Maria Isabel Mesana; Francisco B Ortega; Jonatan R Ruiz; Juan Ezquerra; José A Casajús; Gloria Blay; Vicente A Blay; Marcela Gonzalez-Gross; Luis A Moreno Journal: J Bone Miner Metab Date: 2008-05-11 Impact factor: 2.626
Authors: Andy C Collins; Kenneth D Ward; Barbara S McClanahan; Deborah L Slawson; Christopher Vukadinovich; Kamra E Mays; Nancy Wilson; George Relyea Journal: Clin J Sport Med Date: 2019-01 Impact factor: 3.638
Authors: L Gracia-Marco; F B Ortega; D Jiménez-Pavón; G Rodríguez; M J Castillo; G Vicente-Rodríguez; L A Moreno Journal: Osteoporos Int Date: 2011-05-12 Impact factor: 4.507