Literature DB >> 11786313

Neuroimmunophilin ligands in the treatment of Parkinson's disease.

Bruce G Gold1, John G Nutt.   

Abstract

Parkinson's disease treatments can be divided into three categories: symptomatic, protective and restorative. This review focuses on the restorative and neuroprotective actions of a new class of potential therapeutic agents, neuroimmunophilin ligands. To date, however, short-term treatments with two such compounds in a non-human primate model and in patients with Parkinson's disease have been disappointing.

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Year:  2002        PMID： 11786313     DOI： 10.1016/s1471-4892(01)00125-4

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  7 in total

Review 1.  Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention.

Authors:  Malú G Tansey; Melissa K McCoy; Tamy C Frank-Cannon
Journal:  Exp Neurol       Date:  2007-07-17       Impact factor: 5.330

2.  Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells.

Authors:  Yan Chen; Paul Sternberg; Jiyang Cai
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-04       Impact factor: 4.799

3.  Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson's model: a promising candidate for the treatment of Parkinson's disease.

Authors:  Wu-Fu Chen; Chiranjib Chakraborty; Chun-Sung Sung; Chien-Wei Feng; Yen-Hsuan Jean; Yen-You Lin; Han-Chun Hung; Tzu-Yi Huang; Shi-Ying Huang; Thung-Ming Su; Ping-Jyun Sung; Jyh-Horng Sheu; Zhi-Hong Wen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-11-27       Impact factor: 3.000

Review 4.  Neuroimmune pharmacology from a neuroscience perspective.

Authors:  Nicole A Northrop; Nicole A Northrup; Bryan K Yamamoto
Journal:  J Neuroimmune Pharmacol       Date:  2010-08-18       Impact factor: 4.147

Review 5.  FKBP51 and the molecular chaperoning of metabolism.

Authors:  Kathryn B Smedlund; Edwin R Sanchez; Terry D Hinds
Journal:  Trends Endocrinol Metab       Date:  2021-09-01       Impact factor: 12.015

Review 6.  Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention.

Authors:  Malú G Tansey; Matthew S Goldberg
Journal:  Neurobiol Dis       Date:  2009-11-10       Impact factor: 5.996

7.  Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.

Authors:  Barbara J Bailus; Stephen M Scheeler; Jesse Simons; Maria A Sanchez; Kizito-Tshitoko Tshilenge; Jordi Creus-Muncunill; Swati Naphade; Alejandro Lopez-Ramirez; Ningzhe Zhang; Kuruwitage Lakshika Madushani; Stanislav Moroz; Ashley Loureiro; Katherine H Schreiber; Felix Hausch; Brian K Kennedy; Michelle E Ehrlich; Lisa M Ellerby
Journal:  Autophagy       Date:  2021-05-24       Impact factor: 16.016
  7 in total

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