Bias in dental research can lead to inappropriate treatment selection.

The first RCT was instituted in the early 1950s, evaluating streptomycin and bed rest compared with bed rest alone for tuberculosis. This research design has become the reference standard for comparative evaluations of therapies because of its prospective nature and the ability to control bias. Because it is easier to conduct observational studies, they have often been inappropriately substituted for the better experimental study designs. Since the 1950s, however, readers of the medical literature have slowly come to demand quality clinical research to assist them in caring for their patients. Dentists are somewhat behind their medical colleagues in using the strongest research designs to answer clinical questions. In dentistry, observational studies with convenience samples of patients have been commonly used. It is often argued that few dental ailments affect a person's life as negatively as most medical maladies; therefore, experimental rigors are not required of dental research. Although most dental care does not involve life-and-death issues, dentists are as eager as physicians to offer their patients optimal care. Optimal care is best defined through nonbiased research strategies.