Literature DB >> 117841

9-LR-linoleyl hydroperoxide, a novel product from the oxygenation of linoleic acid by type-2 lipoxygenases from soybeans and peas.

C P van Os, G P Rijke-Schilder, J F Vliegenthart.   

Abstract

Type-2 lipoxygenases from soybeans and peas, which have a pH optimum of 6--7 were examined for oxygenation activity at pH 9.0. The reaction velocity was found to be strongly dependent on substrate concentration. At higher substrate concentrations an inhibitory effect was observed, which is connected with the occurrence of a kinetic lag phase. On incubation of linoleic acid at pH 9.0 with either of these enzymes predominantly 9-LR-hydroperoxy-10-trans,12-cis-octadecadienoic acid is formed. The similarity of the product specificity with that of prostaglandin synthetase is discussed in view of the formation of prostaglandin-like substances by soybean lipoxygenase-2 (Bild, G.S., Bhat, S.G., Ramadoss, C.S. and Axelrod, B. (1978) J. Biol. Chem, 253, 21--23).

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Year:  1979        PMID： 117841     DOI： 10.1016/0005-2760(79)90120-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.

Authors:  Gianguido Coffa; Ann N Imber; Brendan C Maguire; Gurunathan Laxmikanthan; Claus Schneider; Betty J Gaffney; Alan R Brash
Journal:  J Biol Chem       Date:  2005-09-12       Impact factor: 5.157

2.  Regio- and stereospecificity of recombinant soybean lipoxygenase-2.

Authors:  I R Chechetkin; F K Mukhitova; Y V Gogolev; A N Grechkin
Journal:  Dokl Biochem Biophys       Date:  2007 Jul-Aug       Impact factor: 0.788

3.  Effect of nonionic detergents on lipoxygenase catalysis.

Authors:  M J Schilstra; G A Veldink; J F Vliegenthart
Journal:  Lipids       Date:  1994-04       Impact factor: 1.880

4.  Metabolic profile of linoleic acid in stored apples: formation of 13(R)-hydroxy-9(Z),11(E)-octadecadienoic acid.

Authors:  T Beuerle; W Schwab
Journal:  Lipids       Date:  1999-04       Impact factor: 1.880

5.  Intracellular localization of lipoxygenases-1 and -2 in germinating soybean seeds by indirect labeling with protein a-colloidal gold complexes.

Authors:  M Vernooy-Gerritsen; J L Leunissen; G A Veldink; J F Vliegenthart
Journal:  Plant Physiol       Date:  1984-12       Impact factor: 8.340

6.  Localization of lipoxygenases 1 and 2 in germinating soybean seeds by an indirect immunofluorescence technique.

Authors:  M Vernooy-Gerritsen; A L Bos; G A Veldink; J F Vliegenthart
Journal:  Plant Physiol       Date:  1983-10       Impact factor: 8.340

Review 7.  [Cell damage as reason for the formation of unsaturated fatty acid hydroperoxides].

Authors:  C Hölzel; G Spiteller
Journal:  Naturwissenschaften       Date:  1995-10

8.  Polyunsaturated-fatty-acid oxidation in Hydra: regioselectivity, substrate-dependent enantioselectivity and possible biological role.

Authors:  V Di Marzo; C Gianfrani; L De Petrocellis; A Milone; G Cimino
Journal:  Biochem J       Date:  1994-06-01       Impact factor: 3.857

9.  A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple.

Authors:  Doreen Schiller; Carolina Contreras; Jörg Vogt; Frank Dunemann; Bruno G Defilippi; Randolph Beaudry; Wilfried Schwab
Journal:  Hortic Res       Date:  2015-02-25       Impact factor: 6.793
  9 in total

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