L Guo1, Y Liu, W Mao. 1. Nanjing University of TCM, Nanjing (210029).
Abstract
OBJECTIVE: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). METHODS: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. RESULTS: SKI could inhibit the fibronetin, laminin, and type IV collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type IV collagen of ECM but was weaker in intensity. CONCLUSION: The effect of SKI was superior to Benazepril in inhibiting ECM.
OBJECTIVE: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). METHODS: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. RESULTS: SKI could inhibit the fibronetin, laminin, and type IV collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type IV collagen of ECM but was weaker in intensity. CONCLUSION: The effect of SKI was superior to Benazepril in inhibiting ECM.