[Influence of blood-activating drugs on adhesion and invasion of cells in lung cancer patients].

OBJECTIVE: To investigate the influence of some blood-activating drugs like Tetramethylpyrazine, Tanshinone II A, Hirudin and thrombin on adhesive and invasive behavior of PGCL3 and PAa cell lines.
METHODS: Using the above-mentioned blood-activating drugs in various concentration to treat PGCL3 and PAa cells, and the changes in adhesion to fibronectin and invasion in Boyden Chamber of these cells, alone or after interacted with human platelets, were observed.
RESULTS: Tetramethylpyrazine, Hirudin and thrombin could increase the adhesion of cells to fibronectin and Tanshinone II A decrease it. Tetramethylpyrazine, Tanshinone II A and Hirudin inhibited the invasion of PGCL3 cells in Boyden Chamber, and thrombin augmented the process.
CONCLUSION: The blood-activating drugs may either inhibit or promote the invasion and metastasis of PGCL3 and PAa cells in the light of various conditions.