M Zhang1, Z Zhang, T Xia. 1. Department of TCM, Xijing Hospital, Fourth Military Medical University, Xi'an (710032).
Abstract
OBJECTIVE: To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule-1 (sICAM-1), interleukin-15 (IL-15) and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) in patients of Spleen-Deficiency. METHODS:Serum sICAM-1, IL-15 and monocyte ADCC of 66 Spleen-Deficiency patients were determined by enzyme-linked immunosorbent assay and modified thiazole blue test. RESULTS:Serum sICAM-1 of Spleen-Deficiency patients increased, IL-15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above-mentioned parameters were normalized. CONCLUSION:SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi.
RCT Entities:
OBJECTIVE: To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule-1 (sICAM-1), interleukin-15 (IL-15) and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) in patients of Spleen-Deficiency. METHODS: Serum sICAM-1, IL-15 and monocyte ADCC of 66 Spleen-Deficiencypatients were determined by enzyme-linked immunosorbent assay and modified thiazole blue test. RESULTS: Serum sICAM-1 of Spleen-Deficiencypatients increased, IL-15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above-mentioned parameters were normalized. CONCLUSION: SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi.