J Sheng1, Y Chen, J Pan. 1. Department of Gynecology, Beijing Obstetric and Gynecology Hospital, Affiliated to Medical Science of Capital University, Beijing 100006, China.
Abstract
OBJECTIVE: To evaluate the combined use of transvaginal sonography and endometrial cytology for the diagnosis of endometrial disorders in postmenopausal women. METHODS: One hundred forty-three patients with postmenopausal uterine bleeding were studied prospectively. Transvaginal sonography was used to measure the endometrial thickness (double layers), followed by use of the ori endometrial sampler. The results were compared to the histopathologic diagnosis of specimens obtained by dilatation and curettage. RESULTS: When the cutoff point of endometrial thickness was set at 5 mm to detect endometrial malignancy and premalignancy, transvaginal sonography showed a 100.0% sensitivity and 56.9% false positive rate. Endometrial cytology showed a 96.3% specificity but it had a 2.5% false negative rate. The combined use of transvaginal sonography and endometrial cytology can decrease false positive rate of transvaginal sonography from 56.9% to 43.2% (P < 0.01). CONCLUSION: The combined use of transvaginal sonography and endometrial cytology is a good method to screen endometrial malignancy and premalignancy.
OBJECTIVE: To evaluate the combined use of transvaginal sonography and endometrial cytology for the diagnosis of endometrial disorders in postmenopausal women. METHODS: One hundred forty-three patients with postmenopausal uterine bleeding were studied prospectively. Transvaginal sonography was used to measure the endometrial thickness (double layers), followed by use of the ori endometrial sampler. The results were compared to the histopathologic diagnosis of specimens obtained by dilatation and curettage. RESULTS: When the cutoff point of endometrial thickness was set at 5 mm to detect endometrial malignancy and premalignancy, transvaginal sonography showed a 100.0% sensitivity and 56.9% false positive rate. Endometrial cytology showed a 96.3% specificity but it had a 2.5% false negative rate. The combined use of transvaginal sonography and endometrial cytology can decrease false positive rate of transvaginal sonography from 56.9% to 43.2% (P < 0.01). CONCLUSION: The combined use of transvaginal sonography and endometrial cytology is a good method to screen endometrial malignancy and premalignancy.