X Bai1, R Mi. 1. Gynecology and Obstetrics Department, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Abstract
OBJECTIVE: To investigate the expression of VEGF, bFGF and ER in endometrial carcinoma and its relation to the clinico-pathological manifestations and prognosis. METHODS: A total of 66 specimens of endometrial carcinoma and 19 normal endometrium was studied by immunohistological technique with polyclonal antibodies against VEGF and bFGF, and monoclonal antibody against ER. RESULTS: Positive expression rate of VEGF in endometrial carcinoma was 80.3%. Expression of VEGF was positively correlated with tumor grade (P < 0.01). Expression of VEGF was positively correlated with that of bFGF (P < 0.05). Negative correlation was observed between ER expression and tumor grade (P < 0.05). Prognosis of patients with negative ER expression was poor. No correlation existed between ER expression and that of VEGF and bFGF. CONCLUSION: Expression of VEGF and bFGF may indicate that both of them contribute in the angiogenesis of endometrial carcinoma. Expression of ER has prognostic significance.
OBJECTIVE: To investigate the expression of VEGF, bFGF and ER in endometrial carcinoma and its relation to the clinico-pathological manifestations and prognosis. METHODS: A total of 66 specimens of endometrial carcinoma and 19 normal endometrium was studied by immunohistological technique with polyclonal antibodies against VEGF and bFGF, and monoclonal antibody against ER. RESULTS: Positive expression rate of VEGF in endometrial carcinoma was 80.3%. Expression of VEGF was positively correlated with tumor grade (P < 0.01). Expression of VEGF was positively correlated with that of bFGF (P < 0.05). Negative correlation was observed between ER expression and tumor grade (P < 0.05). Prognosis of patients with negative ER expression was poor. No correlation existed between ER expression and that of VEGF and bFGF. CONCLUSION: Expression of VEGF and bFGF may indicate that both of them contribute in the angiogenesis of endometrial carcinoma. Expression of ER has prognostic significance.
Authors: Agnieszka Wanda Piastowska-Ciesielska; Elżbieta Płuciennik; Katarzyna Wójcik-Krowiranda; Andrzej Bieńkiewicz; Andrzej Bednarek; Tomasz Ochędalski Journal: Tumour Biol Date: 2011-12-15