| Literature DB >> 11782252 |
D O'Connor, T Friedrich, A Hughes, T M Allen, D Watkins.
Abstract
Infection of rhesus macaques with simian immunodeficiency virus (SIV) is an excellent model system for studying viral adaptation to immune responses. In this review, we discuss how the SIV-infected macaque has provided unequivocal evidence for cytotoxic T-lymphocyte (CTL) selection of viral escape variants. This improved understanding of CTL escape may influence human immunodeficiency virus (HIV) vaccine design as well as our understanding of HIV pathogenesis.Entities:
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Year: 2001 PMID: 11782252 DOI: 10.1034/j.1600-065x.2001.1830110.x
Source DB: PubMed Journal: Immunol Rev ISSN: 0105-2896 Impact factor: 12.988