Literature DB >> 11781571

Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1.

L C Trotman1, N Mosberger, M Fornerod, R P Stidwill, U F Greber.   

Abstract

Adenovirus type 2 (Ad2) imports its DNA genome through the nuclear pore complex (NPC) of cells in interphase for viral production. Here we identify the NPC-filament protein CAN/Nup214 as a docking site for incoming Ad2 capsids. Binding to CAN is independent of cytosolic factors. Capsids disassemble at NPCs to free their DNA for import. This process requires binding of nuclear histone H1 to the stably docked capsids and involves H1-import factors, restricting this irreversible process to the proximity of the nucleus. Our results provide a molecular mechanism for disassembly of Ad2 and reveal an unexpected function of histone H1 in virus-mediated DNA import.

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Year:  2001        PMID： 11781571     DOI： 10.1038/ncb1201-1092

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  122 in total

1.  Signalling takes control of nucleo-cytoplasmic trafficking. Workshop on signal-regulated nuclear transport.

Authors:  Urs F Greber; Ernesto Carafoli
Journal:  EMBO Rep       Date:  2002-05       Impact factor: 8.807

2.  Association of adenovirus with the microtubule organizing center.

Authors:  Christopher J Bailey; Ronald G Crystal; Philip L Leopold
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

3.  Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals.

Authors:  Harald Wodrich; Tinglu Guan; Gino Cingolani; Dan Von Seggern; Glen Nemerow; Larry Gerace
Journal:  EMBO J       Date:  2003-12-01       Impact factor: 11.598

Review 4.  Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.

Authors:  Pedro R Lowenstein; Donata Suwelack; Jinwei Hu; Xianpeng Yuan; Maximiliano Jimenez-Dalmaroni; Shyam Goverdhana; Maria G Castro
Journal:  Int Rev Neurobiol       Date:  2003       Impact factor: 3.230

5.  Cytoplasmic dynein mediates adenovirus binding to microtubules.

Authors:  Samir A Kelkar; K Kevin Pfister; Ronald G Crystal; Philip L Leopold
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

6.  The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.

Authors:  Dominique Sirena; Benjamin Lilienfeld; Markus Eisenhut; Stefan Kälin; Karin Boucke; Roger R Beerli; Lorenz Vogt; Christiane Ruedl; Martin F Bachmann; Urs F Greber; Silvio Hemmi
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

7.  CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts.

Authors:  Melanie Schmid; Ramon A Gonzalez; Thomas Dobner
Journal:  J Virol       Date:  2011-12-14       Impact factor: 5.103

8.  A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore.

Authors:  F Abaitua; M Hollinshead; M Bolstad; C M Crump; P O'Hare
Journal:  J Virol       Date:  2012-06-20       Impact factor: 5.103

9.  Reduced infectivity of adenovirus type 5 particles and degradation of entering viral genomes associated with incomplete processing of the preterminal protein.

Authors:  Sayuri E Kato; Jasdave S Chahal; S J Flint
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

10.  Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.

Authors:  K Helen Bremner; Julian Scherer; Julie Yi; Michael Vershinin; Steven P Gross; Richard B Vallee
Journal:  Cell Host Microbe       Date:  2009-12-17       Impact factor: 21.023
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