| Literature DB >> 11781417 |
A Misbahuddin1, M R Placzek, K R Chaudhuri, N W Wood, K P Bhatia, T T Warner.
Abstract
Abnormalities in dopamine neurotransmission are thought to underlie the generation of dystonic movements. The authors performed a case-control allelic association study in patients with the focal dystonia blepharospasm, using polymorphisms in the dopamine receptor and transporter genes. Allele 2 of a DRD5 dinucleotide repeat was significantly associated with blepharospasm. This may indicate a pathogenic role for this receptor.Entities:
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Year: 2002 PMID： 11781417 DOI： 10.1212/wnl.58.1.124
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910