OBJECTIVE: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. METHODS: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. RESULTS: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). CONCLUSIONS: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.
OBJECTIVE: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. METHODS: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. RESULTS: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). CONCLUSIONS: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.
Authors: Trung P Nguyen; Jeff Schaffert; Christian LoBue; Kyle B Womack; John Hart; C Munro Cullum Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Anita L DeStefano; Jeanne Latourelle; Mark F Lew; Oksana Suchowersky; Christine Klein; Lawrence I Golbe; Margery H Mark; John H Growdon; G Fredrick Wooten; Ray Watts; Mark Guttman; Brad A Racette; Joel S Perlmutter; Lynn Marlor; Holly A Shill; Carlos Singer; Stefano Goldwurm; Gianni Pezzoli; Marie H Saint-Hilaire; Audrey E Hendricks; Adam Gower; Sally Williamson; Michael W Nagle; Jemma B Wilk; Tiffany Massood; Karen W Huskey; Kenneth B Baker; Ilia Itin; Irene Litvan; Garth Nicholson; Alastair Corbett; Martha Nance; Edward Drasby; Stuart Isaacson; David J Burn; Patrick F Chinnery; Peter P Pramstaller; Jomana Al-Hinti; Anette T Moller; Karen Ostergaard; Scott J Sherman; Richard Roxburgh; Barry Snow; John T Slevin; Franca Cambi; James F Gusella; Richard H Myers Journal: Hum Genet Date: 2008-06-29 Impact factor: 4.132
Authors: J E Tobin; J C Latourelle; M F Lew; C Klein; O Suchowersky; H A Shill; L I Golbe; M H Mark; J H Growdon; G F Wooten; B A Racette; J S Perlmutter; R Watts; M Guttman; K B Baker; S Goldwurm; G Pezzoli; C Singer; M H Saint-Hilaire; A E Hendricks; S Williamson; M W Nagle; J B Wilk; T Massood; J M Laramie; A L DeStefano; I Litvan; G Nicholson; A Corbett; S Isaacson; D J Burn; P F Chinnery; P P Pramstaller; S Sherman; J Al-hinti; E Drasby; M Nance; A T Moller; K Ostergaard; R Roxburgh; B Snow; J T Slevin; F Cambi; J F Gusella; R H Myers Journal: Neurology Date: 2008-05-28 Impact factor: 9.910
Authors: Audrey E Hendricks; Jeanne C Latourelle; Kathryn L Lunetta; L Adrienne Cupples; Vanessa Wheeler; Marcy E MacDonald; James F Gusella; Richard H Myers Journal: Am J Med Genet A Date: 2009-07 Impact factor: 2.802
Authors: Jeanne C Latourelle; Nathan Pankratz; Alexandra Dumitriu; Jemma B Wilk; Stefano Goldwurm; Gianni Pezzoli; Claudio B Mariani; Anita L DeStefano; Cheryl Halter; James F Gusella; William C Nichols; Richard H Myers; Tatiana Foroud Journal: BMC Med Genet Date: 2009-09-22 Impact factor: 2.103