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Literature DB >> 1178071

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials.

R Bayer, D Kalusche, R Kaufmann, R Mannhold.

Abstract

Excitability, maximum velocity of depolarization (MVD), conduction velocity, discharge rate and the duration of transmembrane action potentials as a function of frequency of stimulation were studied in isolated cardiac tissues exposed to the optical isomers of verapamil and D 600.

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Year: 1975 PMID： 1178071 DOI： 10.1007/bf00499991

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

29 in total

Review 1. Heart: electrophysiology.

Authors: S Weidmann
Journal: Annu Rev Physiol Date: 1974 Impact factor: 19.318

2. Adrenaline and the plateau phase of the cardiac action potential. Importance of Ca++, Na+ and K+ conductance.

Authors: E Carmeliet; J Vereecke
Journal: Pflugers Arch Date: 1969 Impact factor: 3.657

3. Calcium-mediated action potentials in mammalian myocardium. Alteration of membrane response as induced by changes of Cae or by promoters and inhibitors of transmembrane Ca inflow.

Authors: H Tritthart; R Volkmann; R Weiss; A Fleckenstein
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

4. Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-Parkinson-White syndrome.

Authors: R A Spurrell; D M Krikler; E Sowton
Journal: Br Heart J Date: 1974-03

5. Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog.

Authors: D P Zipes; J C Fischer
Journal: Circ Res Date: 1974-02 Impact factor: 17.367

6. A fourth class of anti-dysrhythmic action? Effect of verapamil on ouabain toxicity, on atrial and ventricular intracellular potentials, and on other features of cardiac function.

Authors: B N Singh
Journal: Cardiovasc Res Date: 1972-03 Impact factor: 10.787

7. Existence and role of a slow inward current during the frog atrial action potential.

Authors: O Rougier; G Vassort; D Garnier; Y M Gargouil; E Coraboeuf
Journal: Pflugers Arch Date: 1969 Impact factor: 3.657

8. Calcium-dependent action potentials produced by catecholamines in guinea pig atrial muscle fibers depolarized by potassium.

Authors: A J Pappano
Journal: Circ Res Date: 1970-09 Impact factor: 17.367

9. [Electromechanical uncoupling of vascular smooth muscle as the basic principle of coronary dilatation by 4-(2'-nitrophenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (BAY a 1040, Nifedipine). 1. The significance of Ca ++ ions for the bioelectrical and mechanical activity of smooth muscle].

Authors: G Grün; A Fleckenstein
Journal: Arzneimittelforschung Date: 1972-02

10. Conduction of the cardiac impulse. 3. Characteristics of very slow conduction.

Authors: P F Cranefield; A L Wit; B F Hoffman
Journal: J Gen Physiol Date: 1972-02 Impact factor: 4.086

49 in total

1. The effects of diphenylhydantoin on mechanical and electrical properties of isolated cat myocardium.

Authors: R Bayer; R Kaufmann; M Gudjons
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-07 Impact factor: 3.000

2. The effect of verapamil and dibutyryl cAMP on the spontaneous activity of the sinus node.

Authors: W Tuganowski; P Kopéc; M Kopyta; J Wezowska
Journal: Experientia Date: 1977-05-15

3. Incorporation of calcium channels from cardiac sarcolemmal membrane vesicles into planar lipid bilayers.

Authors: B E Ehrlich; C R Schen; M L Garcia; G J Kaczorowski
Journal: Proc Natl Acad Sci U S A Date: 1986-01 Impact factor: 11.205

4. Block of sodium currents by the calcium antagonist D600 in human heart cell segments.

Authors: J O Bustamante
Journal: Pflugers Arch Date: 1985-02 Impact factor: 3.657

5. The action of D600 on frog skeletal muscle: facilitation of excitation-contraction coupling.

Authors: M Dörrscheidt-Käfer
Journal: Pflugers Arch Date: 1977-07-19 Impact factor: 3.657

6. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. I. Pattern of inotropic effects of the racemic compounds.

Authors: R Bayer; R Hennekes; R Kaufmann; R Mannhold
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

7. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. II. Pattern of inotropic effects of the optical isomers.

Authors: R Bayer; R Kaufmann; R Mannhold
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000