OBJECTIVE: To investigate the relationship between tinnitus and glucose metabolism in auditory cortex and whether positron emission tomography (PET) can be an objective tool in measuring tinnitus. METHODS: Eleven right-handed patients with severe tinnitus and ten right-handed control subjects participated in the 18F-FDG/PET study. Analysis with regions of interests was used to calculate asymmetry indices according to the formula: [(L-R) x 100/[(L + R) divided by 2]]. RESULTS: Glucose metabolism in the auditory cortex of tinnitus patients was asymmetric between the left and right auditory cortices, with that of the left being much higher than that of the right. The asymmetry indices of tinnitus patients was significantly higher than that of the control group (unpaired t test, P < 0.001). This revealed that the increased metabolic activity was present in the predominant left hemisphere with a significant focus on the superior and transverse temporal gyri (Brodmann areas 41 and 42, respectively corresponding to primary and secondary auditory cortex), and the results were independent of the subjective localization of the tinnitus sensation. CONCLUSION: It is suggested that the increased metabolism in the left auditory cortex is related to the tinnitus sensation. PET is capable of providing objective evidence for tinnitus and may be used as a potential tool in measuring tinnitus.
OBJECTIVE: To investigate the relationship between tinnitus and glucose metabolism in auditory cortex and whether positron emission tomography (PET) can be an objective tool in measuring tinnitus. METHODS: Eleven right-handed patients with severe tinnitus and ten right-handed control subjects participated in the 18F-FDG/PET study. Analysis with regions of interests was used to calculate asymmetry indices according to the formula: [(L-R) x 100/[(L + R) divided by 2]]. RESULTS:Glucose metabolism in the auditory cortex of tinnituspatients was asymmetric between the left and right auditory cortices, with that of the left being much higher than that of the right. The asymmetry indices of tinnituspatients was significantly higher than that of the control group (unpaired t test, P < 0.001). This revealed that the increased metabolic activity was present in the predominant left hemisphere with a significant focus on the superior and transverse temporal gyri (Brodmann areas 41 and 42, respectively corresponding to primary and secondary auditory cortex), and the results were independent of the subjective localization of the tinnitus sensation. CONCLUSION: It is suggested that the increased metabolism in the left auditory cortex is related to the tinnitus sensation. PET is capable of providing objective evidence for tinnitus and may be used as a potential tool in measuring tinnitus.
Authors: Martin Schecklmann; Michael Landgrebe; Timm B Poeppl; Peter Kreuzer; Peter Männer; Jörg Marienhagen; David S Wack; Tobias Kleinjung; Göran Hajak; Berthold Langguth Journal: Hum Brain Mapp Date: 2011-10-22 Impact factor: 5.038
Authors: A K Paul; E Lobarinas; R Simmons; D Wack; John C Luisi; J Spernyak; R Mazurchuk; H Abdel-Nabi; R Salvi Journal: Neuroimage Date: 2008-10-02 Impact factor: 6.556
Authors: Berthold Langguth; Martin Schecklmann; Astrid Lehner; Michael Landgrebe; Timm Benjamin Poeppl; Peter Michal Kreuzer; Winfried Schlee; Nathan Weisz; Sven Vanneste; Dirk De Ridder Journal: Front Syst Neurosci Date: 2012-04-09
Authors: Saeid Mahmoudian; Mohammad Farhadi; Saeid Gholami; Fariba Saddadi; Ali Reza Karimian; Mohammad Mirzaei; Esmaeel Ghoreyshi; Majid Ahmadizadeh; Thomas Lenarz Journal: J Res Med Sci Date: 2012-03 Impact factor: 1.852