Literature DB >> 11779944

High-sensitivity CCD-based X-ray detector.

Walter C Phillips1, Alexander Stewart, Martin Stanton, Istvan Naday, Charles Ingersoll.   

Abstract

The detector is designed for imaging measurements requiring relatively high sensitivity and high spatial resolution. The detector can discriminate single X-ray photons, yet has the wide dynamic range ( approximately 10000:1) associated with integrating detectors. A GdO2S2 phosphor screen converts the incoming X-ray image into an optical image. The optical image is coupled (without demagnification) to the CCD image sensor using a fiber optic faceplate. The CCD (Philips Semiconductors) has an area of 4.9 x 8.6 cm with 4000 x 7000 12 microm pixels. A single 12 keV X-ray photon produces a signal of 100 e-. With 2 x 2 pixel binning, the total noise per 24 microm pixel in a 100 s image is approximately 30 e- the detective quantum efficiency is >0.6 at 1 X-ray photon per pixel, and the full image can be read out in <4 s. The spatial resolution is 50 microm. The CCD readout system is fully computer-controlled, allowing flexible operation in time-resolved experiments. The detector has been characterized using visible-light images, X-ray images and time-resolved muscle diffraction measurements.

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Year:  2001        PMID: 11779944     DOI: 10.1107/s0909049501020143

Source DB:  PubMed          Journal:  J Synchrotron Radiat        ISSN: 0909-0495            Impact factor:   2.616


  12 in total

1.  The structural basis for regulated assembly and function of the transcriptional activator NtrC.

Authors:  Sacha De Carlo; Baoyu Chen; Timothy R Hoover; Elena Kondrashkina; Eva Nogales; B Tracy Nixon
Journal:  Genes Dev       Date:  2006-06-01       Impact factor: 11.361

2.  Analysis of self-associating proteins by singular value decomposition of solution scattering data.

Authors:  Tim E Williamson; Bruce A Craig; Elena Kondrashkina; Chris Bailey-Kellogg; Alan M Friedman
Journal:  Biophys J       Date:  2008-01-22       Impact factor: 4.033

3.  Cost-effective EMCCD-based detector for time-resolved biological SAXS applications.

Authors:  Vivek V Nagarkar; Bipin Singh; Liang Guo; David Gore; Thomas C Irving
Journal:  Nucl Instrum Methods Phys Res A       Date:  2007-06-11       Impact factor: 1.455

4.  RECENT IMPROVEMENTS IN SMALL ANGLE X-RAY DIFFRACTION FOR THE STUDY OF MUSCLE PHYSIOLOGY.

Authors:  Massimo Reconditi
Journal:  Rep Prog Phys       Date:  2006-10-01

5.  Bayesian reconstruction of P(r) directly from two-dimensional detector images via a Markov chain Monte Carlo method.

Authors:  Sudeshna Paul; Alan M Friedman; Chris Bailey-Kellogg; Bruce A Craig
Journal:  J Appl Crystallogr       Date:  2013-03-05       Impact factor: 3.304

6.  ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54.

Authors:  Baoyu Chen; Michaeleen Doucleff; David E Wemmer; Sacha De Carlo; Hector H Huang; Eva Nogales; Timothy R Hoover; Elena Kondrashkina; Liang Guo; B Tracy Nixon
Journal:  Structure       Date:  2007-04       Impact factor: 5.006

7.  In situ D-periodic molecular structure of type II collagen.

Authors:  Olga Antipova; Joseph P R O Orgel
Journal:  J Biol Chem       Date:  2010-01-06       Impact factor: 5.157

8.  Mixtures of cationic lipid O-ethylphosphatidylcholine with membrane lipids and DNA: phase diagrams.

Authors:  Rumiana Koynova; Robert C MacDonald
Journal:  Biophys J       Date:  2003-10       Impact factor: 4.033

9.  Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction.

Authors:  Kanji Oshima; Yasunobu Sugimoto; Thomas C Irving; Katsuzo Wakabayashi
Journal:  PLoS One       Date:  2012-12-20       Impact factor: 3.240

10.  Experience with exchange and archiving of raw data: comparison of data from two diffractometers and four software packages on a series of lysozyme crystals.

Authors:  Simon W M Tanley; Antoine M M Schreurs; John R Helliwell; Loes M J Kroon-Batenburg
Journal:  J Appl Crystallogr       Date:  2012-12-08       Impact factor: 3.304

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