Literature DB >> 11779695

Autoinhibition of Sos by intramolecular interactions.

Brian E Hall1, Shao-Song Yang, Dafna Bar-Sagi.   

Abstract

Sos proteins function as activators of Ras signaling by catalyzing guanine nucleotide exchange on Ras. Sos regulation was initially thought to be accomplished primarily through its growth factor-dependent recruitment to the plasma membrane. More recent data has indicated that while membrane association is an indispensable means of Sos regulation, additional mechanisms involving intramolecular interactions function to control Sos activity towards Ras. This review will examine the experimental evidence for Sos intramolecular interactions and their contribution to Sos regulation.

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Year:  2002        PMID： 11779695     DOI： 10.2741/hall

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  7 in total

Review 1.  Determinants of substrate recognition in nonreceptor tyrosine kinases.

Authors:  W Todd Miller
Journal:  Acc Chem Res       Date:  2003-06       Impact factor: 22.384

2.  Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.

Authors:  Holger Sondermann; Bhushan Nagar; Dafna Bar-Sagi; John Kuriyan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-02       Impact factor: 11.205

3.  Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.

Authors:  José M Rojas; José Luis Oliva; Eugenio Santos
Journal:  Genes Cancer       Date:  2011-03

4.  Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

Authors:  Jonathan P DiNitto; Anna Delprato; Meng-Tse Gabe Lee; Thomas C Cronin; Shaohui Huang; Adilson Guilherme; Michael P Czech; David G Lambright
Journal:  Mol Cell       Date:  2007-11-30       Impact factor: 17.970

5.  Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).

Authors:  Mei Ying Ng; Mei Wang; Patrick J Casey; Yunn-Hwen Gan; Thilo Hagen
Journal:  PLoS One       Date:  2017-02-06       Impact factor: 3.240

Review 6.  The Interdependent Activation of Son-of-Sevenless and Ras.

Authors:  Pradeep Bandaru; Yasushi Kondo; John Kuriyan
Journal:  Cold Spring Harb Perspect Med       Date:  2019-02-01       Impact factor: 6.915

7.  Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.

Authors:  Janelle Lauer; Sandra Segeletz; Alice Cezanne; Giambattista Guaitoli; Francesco Raimondi; Marc Gentzel; Vikram Alva; Michael Habeck; Yannis Kalaidzidis; Marius Ueffing; Andrei N Lupas; Christian Johannes Gloeckner; Marino Zerial
Journal:  Elife       Date:  2019-11-13       Impact factor: 8.713
  7 in total

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