OBJECTIVE: To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium. DESIGN: Retrospective chart review. SETTING: University-based assisted reproduction and oncology units. PATIENT(S): One patient who had two separate pregnancies. INTERVENTION(S): High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte. MAIN OUTCOME MEASURE(S): Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries. RESULT(S): The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction. CONCLUSION(S): Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing.
OBJECTIVE: To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium. DESIGN: Retrospective chart review. SETTING: University-based assisted reproduction and oncology units. PATIENT(S): One patient who had two separate pregnancies. INTERVENTION(S): High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte. MAIN OUTCOME MEASURE(S): Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries. RESULT(S): The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction. CONCLUSION(S): Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing.
Authors: Susan D Reed; Linda F Voigt; Katherine M Newton; Rochelle H Garcia; H Kimberly Allison; Meira Epplein; Diana Jordan; Elizabeth Swisher; Noel S Weiss Journal: Obstet Gynecol Date: 2009-03 Impact factor: 7.661