Literature DB >> 11779031

Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat.

S Canpolat1, S Sandal, B Yilmaz, A Yasar, S Kutlu, G Baydas, H Kelestimur.   

Abstract

The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats (P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release.

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Year:  2001        PMID： 11779031     DOI： 10.1016/s0014-2999(01)01230-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.

Authors:  Adrian Rubio-González; Juan Carlos Bermejo-Millo; Beatriz de Luxán-Delgado; Yaiza Potes; Zulema Pérez-Martínez; José Antonio Boga; Ignacio Vega-Naredo; Beatriz Caballero; Juan José Solano; Ana Coto-Montes
Journal:  Mol Neurobiol       Date:  2017-10-30       Impact factor: 5.590

2.  Genomic evidence for the parallel regression of melatonin synthesis and signaling pathways in placental mammals [version 2; peer review: 2 approved].

Authors:  Christopher A Emerling; Mark S Springer; John Gatesy; Zachary Jones; Deana Hamilton; David Xia-Zhu; Matt Collin; Frédéric Delsuc
Journal:  Open Res Eur       Date:  2021-12-13

Review 3.  Physiological and metabolic functions of melatonin.

Authors:  J Barrenetxe; P Delagrange; J A Martínez
Journal:  J Physiol Biochem       Date:  2004-03       Impact factor: 4.158

4.  Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides.

Authors:  Karamat Allah Solhjou; Seyed Ebrahim Hosseini; Akbar Vahdati; Mohammad Amin Edalatmanesh
Journal:  Iran J Med Sci       Date:  2019-03

5.  Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland.

Authors:  Rodrigo Antonio Peliciari-Garcia; Jéssica Andrade-Silva; José Cipolla-Neto; Carla Roberta de Oliveira Carvalho
Journal:  Biomed Res Int       Date:  2013-07-01       Impact factor: 3.411

6.  Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats.

Authors:  Daniella Buonfiglio; Rafaela Parthimos; Rosana Dantas; Raysa Cerqueira Silva; Guilherme Gomes; Jéssica Andrade-Silva; Angela Ramos-Lobo; Fernanda Gaspar Amaral; Raphael Matos; José Sinésio; Lívia Clemente Motta-Teixeira; José Donato; Russel J Reiter; José Cipolla-Neto
Journal:  Front Endocrinol (Lausanne)       Date:  2018-03-27       Impact factor: 5.555
  6 in total

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