Literature DB >> 11777857

Biological activity of a mouse-human chimeric immunoglobulin G2 antibody to Cryptococcus neoformans polysaccharide.

Katherine Westin Kwon1, Nikoletta Lendvai, Sherie Morrison, K Ryan Trinh, Arturo Casadevall.   

Abstract

The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.

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Year:  2002        PMID： 11777857      PMCID： PMC119884          DOI： 10.1128/cdli.9.1.201-204.2002

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  21 in total

Review 1.  Passive antibody therapies: progress and continuing challenges.

Authors:  A Casadevall
Journal:  Clin Immunol       Date:  1999-10       Impact factor: 3.969

2.  H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate.

Authors:  L J Cooper; J C Schimenti; D D Glass; N S Greenspan
Journal:  J Immunol       Date:  1991-04-15       Impact factor: 5.422

3.  Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection.

Authors:  A Casadevall; J Mukherjee; S J Devi; R Schneerson; J B Robbins; M D Scharff
Journal:  J Infect Dis       Date:  1992-06       Impact factor: 5.226

4.  Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice.

Authors:  N Lendvai; X W Qu; W Hsueh; A Casadevall
Journal:  J Immunol       Date:  2000-04-15       Impact factor: 5.422

5.  Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains.

Authors:  L J Cooper; A R Shikhman; D D Glass; D Kangisser; M W Cunningham; N S Greenspan
Journal:  J Immunol       Date:  1993-03-15       Impact factor: 5.422

6.  Persistence of initial infection in recurrent Cryptococcus neoformans meningitis.

Authors:  E D Spitzer; S G Spitzer; L F Freundlich; A Casadevall
Journal:  Lancet       Date:  1993-03-06       Impact factor: 79.321

7.  Mouse-human immunoglobulin G1 chimeric antibodies with activities against Cryptococcus neoformans.

Authors:  S L Zebedee; R K Koduri; J Mukherjee; S Mukherjee; S Lee; D F Sauer; M D Scharff; A Casadevall
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

8.  Monoclonal antibody based ELISAs for cryptococcal polysaccharide.

Authors:  A Casadevall; J Mukherjee; M D Scharff
Journal:  J Immunol Methods       Date:  1992-09-18       Impact factor: 2.303

9.  Protective murine monoclonal antibodies to Cryptococcus neoformans.

Authors:  J Mukherjee; M D Scharff; A Casadevall
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

10.  Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody.

Authors:  R Yuan; A Casadevall; G Spira; M D Scharff
Journal:  J Immunol       Date:  1995-02-15       Impact factor: 5.422
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  1 in total

Review 1.  Monoclonal Antibodies as Tools to Combat Fungal Infections.

Authors:  Sebastian Ulrich; Frank Ebel
Journal:  J Fungi (Basel)       Date:  2020-02-04
  1 in total

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