| Literature DB >> 11777434 |
Lanrong Bi1, Ming Zhao, Chao Wang, Shiqi Peng, Ekkehard Winterfeldt.
Abstract
The synthesis of a series of enantiopure malonaldehyde monocycloacetals is described. Treatment of 8b with L-tryptophan methyl ester, 5-methoxytryptamine, and tryptamine, respectively, in the Pictet-Spengler condensation gave the corresponding enantiomerically pure key precursors 1-3 and 17-21 in only two steps. Using a chiral amino-diol successfully realized the kinetic resolution of racemic carbolines 23 and 24.Entities:
Year: 2002 PMID： 11777434 DOI： 10.1021/jo0057351
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354