J Da1, H Shi, J Lu. 1. Air Force General Hospital of PLA, Beijing 100036.
Abstract
OBJECTIVE: To report 8 cases of squamous-cell carcinoma showing thymus-like element (CASTLE) of the thyroid. METHODS: Clinical data and pathological sections were retrospectively reviewed. RESULTS: CASTLE of the thyroid differed from ordinary squamous-cell carcinoma (SCC) in that it not only presented typical squamous pattern of differentiation, but also admixed with thymic architecture, such as Hassall's corpuscles, lymphoepithelial-like structure and mature lymphocyte infiltration in the stroma. CASTLE of the thyroid and much better prognosis than that of the ordinary SCC of the thyroid with a median survival time of 10.5 year. Histogenesis of CASTLE was discussed. CONCLUSION: Thyroid CASTLE is of rare occurrence. It should be distinguished from SCC of thyroid in order to treat such patients adequately.
OBJECTIVE: To report 8 cases of squamous-cell carcinoma showing thymus-like element (CASTLE) of the thyroid. METHODS: Clinical data and pathological sections were retrospectively reviewed. RESULTS: CASTLE of the thyroid differed from ordinary squamous-cell carcinoma (SCC) in that it not only presented typical squamous pattern of differentiation, but also admixed with thymic architecture, such as Hassall's corpuscles, lymphoepithelial-like structure and mature lymphocyte infiltration in the stroma. CASTLE of the thyroid and much better prognosis than that of the ordinary SCC of the thyroid with a median survival time of 10.5 year. Histogenesis of CASTLE was discussed. CONCLUSION: Thyroid CASTLE is of rare occurrence. It should be distinguished from SCC of thyroid in order to treat such patients adequately.
Authors: Christina Maria Steger; Moritz von Frankenberg; Christoph Kahlert; Gunhild Mechtersheimer; Hansjoerg Steiner; Peter Schirmacher; Ralf Joachim Rieker Journal: BMJ Case Rep Date: 2009-12-14