Literature DB >> 1177672

Bile acid metabolism in mammals: IX. Conversion of chenodeoxycholic acid to cholic acid by isolated perfused rat liver.

I M Yousef, M M Fisher.   

Abstract

Current dogma of bile acid synthesis in mammals insists that hydroxylation of the ring structure at C-12 precedes side chain oxidation, and that chenodeoxycholic acid is not converted to cholic acid under normal conditions. This report concerns the conversion of chenodeoxycholic acid to cholic acid by isolated, perfused rat liver. Results indicate that isolated perfused rat liver has a definite, but limited, capacity for synthesis of cholic acid from chenodeoxycholic acid.

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Year:  1975        PMID： 1177672     DOI： 10.1007/bf02532365

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

1.  AMINO ACID METABOLISM IN THE PERFUSED RAT LIVER.

Authors:  M M FISHER; M KERLY
Journal:  J Physiol       Date:  1964-11       Impact factor: 5.182

Review 2.  PRESENT STATUS OF RESEARCH ON CATABOLISM AND EXCRETION OF CHOLESTEROL.

Authors:  H DANIELSSON
Journal:  Adv Lipid Res       Date:  1963

Review 3.  Enzymatic regulation of bile acid synthesis.

Authors:  G S Boyd; I W Percy-Robb
Journal:  Am J Med       Date:  1971-11       Impact factor: 4.965

4.  Bile acid metabolism in mammals. V. Studies on the sex difference in the response of the isolated perfused rat liver to chenodeoxycholic acid.

Authors:  I M Yousef; R Magnusson; V M Price; M M Fisher
Journal:  Can J Physiol Pharmacol       Date:  1973-06       Impact factor: 2.273

5.  Secretion of bile salts by intact and isolated rat livers.

Authors:  M T Subbiah; A Kuksis; S Mookerjea
Journal:  Can J Biochem       Date:  1969-09

6.  Bile acid metabolism in mammals. I. Bile acid-induced intrahepatic cholestasis.

Authors:  M M Fisher; R Magnusson; K Miyai
Journal:  Lab Invest       Date:  1971-07       Impact factor: 5.662

7.  Sterio-bile acids and bile alcohols. CI. 12-alpha-hydroxylation of chenodeoxycholic acid in eel liver.

Authors:  T Masui; F Yeyama; H Yashima; T Kazuno
Journal:  J Biochem       Date:  1967-12       Impact factor: 3.387

8.  Bile acids and steroids. 98. The metabolism of bile acids in python and constrictor snakes.

Authors:  S BERGSTROM; H DANIELSSON; T KAZUNO
Journal:  J Biol Chem       Date:  1960-04       Impact factor: 5.157

9.  Bile acid composition of rainbow trout, Salmo gairdneri.

Authors:  J E Denton; M K Yousef; I M Yousef
Journal:  Lipids       Date:  1974-12       Impact factor: 1.880

10.  Bile acid metabolism in mammals. 3. Sex difference in the bile acid composition of rat bile.

Authors:  I M Yousef; G Kakis; M M Fisher
Journal:  Can J Biochem       Date:  1972-04
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  1 in total

1.  Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.

Authors:  Iván L Csanaky; Hong Lu; Youcai Zhang; Kenichiro Ogura; Supratim Choudhuri; Curtis D Klaassen
Journal:  Hepatology       Date:  2010-10-14       Impact factor: 17.425
  1 in total

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