X Bai1, R Mi. 1. Department of Obstetrics and Gynecology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Abstract
OBJECTIVE: To investigate the relation of basic fibroblastic growth factor (bFGF) and microvessel density (MVD) with endometrial carcinoma. METHODS: A total of 66 specimens of endometrial carcinoma were evaluated by immunohistochemical technique with polyclonal antibody against bFGF. The microvessels were highlight by immunohistologically staining to detect factor VIII-related antigen. The area of the deepest myometrial invasion was selected for staining. Ninteen specimens of uterine prolapse were used for control. RESULTS: Expression of bFGF was significantly correlated with tumor grade (P < 0.01). MVD was positively correlated with age, tumor grade and myometrial invasion (P < 0.01, respectively). MVD was significantly correlated with expression of bFGF (P < 0.01). Patients with bFGF strong expression and high MVD (> or = 9.4) had worse prognosis (P < 0.01, respectively). CONCLUSIONS: bFGF plays important role in angiogenesis in endometrial carcinoma. Expression of bFGF and MVD could be used as prognostic factors for survival in endometrial carcinoma.
OBJECTIVE: To investigate the relation of basic fibroblastic growth factor (bFGF) and microvessel density (MVD) with endometrial carcinoma. METHODS: A total of 66 specimens of endometrial carcinoma were evaluated by immunohistochemical technique with polyclonal antibody against bFGF. The microvessels were highlight by immunohistologically staining to detect factor VIII-related antigen. The area of the deepest myometrial invasion was selected for staining. Ninteen specimens of uterine prolapse were used for control. RESULTS: Expression of bFGF was significantly correlated with tumor grade (P < 0.01). MVD was positively correlated with age, tumor grade and myometrial invasion (P < 0.01, respectively). MVD was significantly correlated with expression of bFGF (P < 0.01). Patients with bFGF strong expression and high MVD (> or = 9.4) had worse prognosis (P < 0.01, respectively). CONCLUSIONS:bFGF plays important role in angiogenesis in endometrial carcinoma. Expression of bFGF and MVD could be used as prognostic factors for survival in endometrial carcinoma.
Authors: D Scott McMeekin; Michael W Sill; Doris Benbrook; Kathleen M Darcy; Deborah J Stearns-Kurosawa; Lynne Eaton; S Diane Yamada Journal: Gynecol Oncol Date: 2007-02-15 Impact factor: 5.482