Y Peng1, S Ma, S Zhang, Y Li, L Yang, S Bian. 1. Department of Cardiology, Hebei Provincial People's Hospital, Shijiazhuang 050051, China.
Abstract
OBJECTIVE: To explore the relationship of beta-adrenoreceptor density and function with the condition of patients with essential hypertension. METHODS: In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age-matched normotensive controls. beta-adrenoreceptor maximum bound volume (Bmax) in peripheral lymphocytes was measured by 3H-dihydroalprenolol (3 H-DHA) radio ligand binding. beta-adrenoreceptor responsiveness was determined by Salbutamol (injection). RESULTS: In patients with essential hypertension at stages I and II, Bmax was significantly higher (P < 0.01 and P < 0.001, respectively) and the chronotropic doses of Salbutamol required to increase the heart rate by 30 beats/min (CD30) were significantly lower (P < 0.01 and P < 0.001, respectively) than in age-matched normotensive control subjects. In patients with essential hypertension at stage III, Bmax was significantly lower and CD30 was significantly higher (both P < 0.01) than those in the age-matched normotensive control subjects. Bmax was significantly higher and CD30 was significantly lower (both P < 0.001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH. In patients with essential hypertension and heart failure, Bmax was significantly lower and CD30 was significantly higher (both P < 0.001) than those in patients with essential hypertension without heart failure. CONCLUSIONS: The changes of beta-adrenoreceptor density and function were related to hypertension, hypertension complicated with ventricular hypertrophy, and heart failure. They may be viewed as indexes of the condition in the patients with essential hypertension.
OBJECTIVE: To explore the relationship of beta-adrenoreceptor density and function with the condition of patients with essential hypertension. METHODS: In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age-matched normotensive controls. beta-adrenoreceptor maximum bound volume (Bmax) in peripheral lymphocytes was measured by 3H-dihydroalprenolol (3 H-DHA) radio ligand binding. beta-adrenoreceptor responsiveness was determined by Salbutamol (injection). RESULTS: In patients with essential hypertension at stages I and II, Bmax was significantly higher (P < 0.01 and P < 0.001, respectively) and the chronotropic doses of Salbutamol required to increase the heart rate by 30 beats/min (CD30) were significantly lower (P < 0.01 and P < 0.001, respectively) than in age-matched normotensive control subjects. In patients with essential hypertension at stage III, Bmax was significantly lower and CD30 was significantly higher (both P < 0.01) than those in the age-matched normotensive control subjects. Bmax was significantly higher and CD30 was significantly lower (both P < 0.001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH. In patients with essential hypertension and heart failure, Bmax was significantly lower and CD30 was significantly higher (both P < 0.001) than those in patients with essential hypertension without heart failure. CONCLUSIONS: The changes of beta-adrenoreceptor density and function were related to hypertension, hypertension complicated with ventricular hypertrophy, and heart failure. They may be viewed as indexes of the condition in the patients with essential hypertension.
Authors: Gabriele Giacomo Schiattarella; Fabio Magliulo; Fabio Cattaneo; Giuseppe Gargiulo; Anna Sannino; Anna Franzone; Marco Oliveti; Cinzia Perrino; Bruno Trimarco; Giovanni Esposito Journal: Front Cardiovasc Med Date: 2015-03-16