OBJECTIVE: Our purpose was to find out if morphometric techniques can document long term changes in gastric antral atrophy after curing Helicobacter pylori infection with or without dietary supplementation with antioxidant micronutrients. METHODS:Study subjects were 132 adult volunteers from a Colombian region with high gastric cancer rates. Participants were randomly assigned to ascorbic acid, beta-carotene, and anti-H. pylori treatment, following a factorial design. Gastric biopsies were obtained at baseline and after 72 months of intervention. Atrophy was evaluated by a standard visual analog scale and by morphometry. RESULTS: Statistically significant changes in antral atrophy were detected with morphometric techniques after intervention in subjects who received anti-H. pylori treatment. A nonsignificant trend was also observed with visual scores. This effect was greater among those who were free of infection at the end of the trial. After accounting for the effect of anti-H. pylori treatment, no significant effect was noted for dietary supplementation with ascorbic acid and/or beta-carotene. CONCLUSIONS: We conclude that gastric atrophy improves significantly after long term control of H. pylori infection. This effect can be demonstrated both by conventional histological grading and by morphometry.
RCT Entities:
OBJECTIVE: Our purpose was to find out if morphometric techniques can document long term changes in gastric antral atrophy after curing Helicobacter pyloriinfection with or without dietary supplementation with antioxidant micronutrients. METHODS: Study subjects were 132 adult volunteers from a Colombian region with high gastric cancer rates. Participants were randomly assigned to ascorbic acid, beta-carotene, and anti-H. pylori treatment, following a factorial design. Gastric biopsies were obtained at baseline and after 72 months of intervention. Atrophy was evaluated by a standard visual analog scale and by morphometry. RESULTS: Statistically significant changes in antral atrophy were detected with morphometric techniques after intervention in subjects who received anti-H. pylori treatment. A nonsignificant trend was also observed with visual scores. This effect was greater among those who were free of infection at the end of the trial. After accounting for the effect of anti-H. pylori treatment, no significant effect was noted for dietary supplementation with ascorbic acid and/or beta-carotene. CONCLUSIONS: We conclude that gastric atrophy improves significantly after long term control of H. pyloriinfection. This effect can be demonstrated both by conventional histological grading and by morphometry.
Authors: Robertino Mera; Elizabeth T H Fontham; Luis E Bravo; Juan C Bravo; Maria Blanca Piazuelo; Maria Constanza Camargo; Pelayo Correa Journal: Gut Date: 2007-03 Impact factor: 23.059
Authors: Massimo Rugge; Alberto Meggio; Gianmaria Pennelli; Francesco Piscioli; Luciano Giacomelli; Giovanni De Pretis; David Y Graham Journal: Gut Date: 2006-12-01 Impact factor: 23.059
Authors: Jone Garay; M Blanca Piazuelo; Sumana Majumdar; Li Li; Jimena Trillo-Tinoco; Luis Del Valle; Barbara G Schneider; Alberto G Delgado; Keith T Wilson; Pelayo Correa; Jovanny Zabaleta Journal: Cancer Lett Date: 2015-11-27 Impact factor: 8.679