Matthew L Snyder1, Augusto F G Paulino. 1. Department of Pathology, University of Michigan Hospitals, 1500 East Medical Center Drive, Room 2G332, Ann Arbor, MI 48109, USA.
Abstract
BACKGROUND: Sinonasal melanomas are rare neoplasms whose diagnosis may require confirmatory immunohistochemical stains. S-100 protein and HMB-45, the stains most commonly used, have varying sensitivities and specificities. Melan-A, a more recent melanoma-specific marker, may prove helpful when S-100 protein and HMB-45 stains are negative or equivocal. METHODS: Seven cases of sinonasal melanoma were assessed for reactivity with Melan-A, S-100 protein and HMB-45. RESULTS: The study group consisted of two women and five men ages 40 to 83. Six of the neoplasms were strongly positive for S-100 protein. One case was negative for S-100 protein and HMB-45 but positive for Melan-A. HMB-45 staining varied between diffusely positive (three cases), focally positive (two cases), and negative (two cases). All cases were positive for Melan-A either diffusely (four cases) or focally (three cases). CONCLUSION: Because Melan-A can be positive in cases that are S-100 protein or HMB-45 negative, it is a useful component in the immunohistochemical panel for the diagnosis of sinonasal melanomas. Copyright 2002 John Wiley & Sons, Inc.
BACKGROUND:Sinonasal melanomas are rare neoplasms whose diagnosis may require confirmatory immunohistochemical stains. S-100 protein and HMB-45, the stains most commonly used, have varying sensitivities and specificities. Melan-A, a more recent melanoma-specific marker, may prove helpful when S-100 protein and HMB-45 stains are negative or equivocal. METHODS: Seven cases of sinonasal melanoma were assessed for reactivity with Melan-A, S-100 protein and HMB-45. RESULTS: The study group consisted of two women and five men ages 40 to 83. Six of the neoplasms were strongly positive for S-100 protein. One case was negative for S-100 protein and HMB-45 but positive for Melan-A. HMB-45 staining varied between diffusely positive (three cases), focally positive (two cases), and negative (two cases). All cases were positive for Melan-A either diffusely (four cases) or focally (three cases). CONCLUSION: Because Melan-A can be positive in cases that are S-100 protein or HMB-45 negative, it is a useful component in the immunohistochemical panel for the diagnosis of sinonasal melanomas. Copyright 2002 John Wiley & Sons, Inc.
Authors: Simon Andreasen; Justin A Bishop; Henrik Hellquist; Jennifer Hunt; Katalin Kiss; Alessandra Rinaldo; Alena Skálová; Stefan M Willems; Michelle Williams; Alfio Ferlito Journal: Virchows Arch Date: 2018-08-14 Impact factor: 4.064