BACKGROUND: Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability. AIMS: To estimate the heritability of the nuclear syndrome. METHOD: A total of 224 twin pairs (106 monozygotic, 118 same-gender dizygotic) were ascertained from the Maudsley Twin Register in London via probands with any psychosis. Lifetime-ever first-rank symptoms were rated using the OPCRIT checklist. Probandwise concordance rates were calculated for the nuclear syndrome and a heritability estimate was derived from biometric model fitting. RESULTS: Probandwise concordance rates were 13/49 (26.5%) for monozygotic and 0/45 to 2/46 (0.0-4.3%) for dizygotic pairs. The heritability estimate for the best-fitting model was 71% (95% CI 57-82). CONCLUSIONS: These results indicate that the nuclear syndrome shows substantial heritability, although this is slightly lower than that for schizophrenia as defined by the DSM and ICD systems.
BACKGROUND: Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability. AIMS: To estimate the heritability of the nuclear syndrome. METHOD: A total of 224 twin pairs (106 monozygotic, 118 same-gender dizygotic) were ascertained from the Maudsley Twin Register in London via probands with any psychosis. Lifetime-ever first-rank symptoms were rated using the OPCRIT checklist. Probandwise concordance rates were calculated for the nuclear syndrome and a heritability estimate was derived from biometric model fitting. RESULTS: Probandwise concordance rates were 13/49 (26.5%) for monozygotic and 0/45 to 2/46 (0.0-4.3%) for dizygotic pairs. The heritability estimate for the best-fitting model was 71% (95% CI 57-82). CONCLUSIONS: These results indicate that the nuclear syndrome shows substantial heritability, although this is slightly lower than that for schizophrenia as defined by the DSM and ICD systems.
Authors: Pei-Lung Chen; Dimitrios Avramopoulos; Virginia K Lasseter; John A McGrath; M Daniele Fallin; Kung-Yee Liang; Gerald Nestadt; Ningping Feng; Gary Steel; Andrew S Cutting; Paula Wolyniec; Ann E Pulver; David Valle Journal: Am J Hum Genet Date: 2009-01 Impact factor: 11.025
Authors: Philip J Brittain; Daniel Stahl; James Rucker; Jamie Kawadler; Gunter Schumann Journal: Int J Methods Psychiatr Res Date: 2013-05-09 Impact factor: 4.035
Authors: Diego Quattrone; Ulrich Reininghaus; Alex L Richards; Giada Tripoli; Laura Ferraro; Andrea Quattrone; Paolo Marino; Victoria Rodriguez; Edoardo Spinazzola; Charlotte Gayer-Anderson; Hannah E Jongsma; Peter B Jones; Caterina La Cascia; Daniele La Barbera; Ilaria Tarricone; Elena Bonora; Sarah Tosato; Antonio Lasalvia; Andrei Szöke; Celso Arango; Miquel Bernardo; Julio Bobes; Cristina Marta Del Ben; Paulo Rossi Menezes; Pierre-Michel Llorca; Jose Luis Santos; Julio Sanjuán; Manuel Arrojo; Andrea Tortelli; Eva Velthorst; Steven Berendsen; Lieuwe de Haan; Bart P F Rutten; Michael T Lynskey; Tom P Freeman; James B Kirkbride; Pak C Sham; Michael C O'Donovan; Alastair G Cardno; Evangelos Vassos; Jim van Os; Craig Morgan; Robin M Murray; Cathryn M Lewis; Marta Di Forti Journal: Transl Psychiatry Date: 2021-08-10 Impact factor: 6.222