BACKGROUND: Neuroendocrine studies of brain serotonin (5-HT) function in depression generally show evidence of impaired 5-HT function but it is disputed whether or not this impairment resolves with clinical recovery. AIMS: To use the endocrine response to the selective 5-HT reuptake inhibitor, citalopram, to study brain 5-HT function in acute and recovered depressed subjects relative to healthy controls. METHOD: We used a double-blind, placebo-controlled design to measure the prolactin and cortisol responses to citalopram (10 mg intravenously) in patients with major depression, in unmedicated subjects recovered from depression and in healthy controls. RESULTS: The prolactin responses to citalopram were blunted similarly in both acutely depressed and recovered subjects. The cortisol responses were blunted in the acutely depressed patients but not in the recovered subjects. CONCLUSIONS: Our data support the proposal that some aspects of impaired 5-HT neurotransmission may be trait markers of vulnerability to depression. The recovery of the cortisol response to citalopram may indicate resolution of hypothalamic-pituitary-adrenal axis dysfunction.
RCT Entities:
BACKGROUND: Neuroendocrine studies of brain serotonin (5-HT) function in depression generally show evidence of impaired 5-HT function but it is disputed whether or not this impairment resolves with clinical recovery. AIMS: To use the endocrine response to the selective 5-HT reuptake inhibitor, citalopram, to study brain 5-HT function in acute and recovered depressed subjects relative to healthy controls. METHOD: We used a double-blind, placebo-controlled design to measure the prolactin and cortisol responses to citalopram (10 mg intravenously) in patients with major depression, in unmedicated subjects recovered from depression and in healthy controls. RESULTS: The prolactin responses to citalopram were blunted similarly in both acutely depressed and recovered subjects. The cortisol responses were blunted in the acutely depressedpatients but not in the recovered subjects. CONCLUSIONS: Our data support the proposal that some aspects of impaired 5-HT neurotransmission may be trait markers of vulnerability to depression. The recovery of the cortisol response to citalopram may indicate resolution of hypothalamic-pituitary-adrenal axis dysfunction.
Authors: Jeffrey M Miller; Natalie Hesselgrave; R Todd Ogden; Gregory M Sullivan; Maria A Oquendo; J John Mann; Ramin V Parsey Journal: Biol Psychiatry Date: 2013-03-01 Impact factor: 13.382
Authors: Jeffrey M Miller; Erin L Kinnally; R Todd Ogden; Maria A Oquendo; J John Mann; Ramin V Parsey Journal: Synapse Date: 2009-07 Impact factor: 2.562
Authors: John G Keilp; Maria A Oquendo; Barbara H Stanley; Ainsley K Burke; Thomas B Cooper; Kevin M Malone; J John Mann Journal: Neuropsychopharmacology Date: 2008-03-19 Impact factor: 7.853
Authors: Jeffrey M Miller; Kathleen G Brennan; Todd R Ogden; Maria A Oquendo; Gregory M Sullivan; J John Mann; Ramin V Parsey Journal: Neuropsychopharmacology Date: 2009-05-20 Impact factor: 7.853