| Literature DB >> 1177259 |
E H Banitt, W E Coyne, J R Schmid, A Mendel.
Abstract
Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy groups. The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.Entities:
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Year: 1975 PMID： 1177259 DOI： 10.1021/jm00245a017
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446