F D Malone1, A Athanassiou, L A Nores, M E Dalton. 1. Division of Material-Fetal Medicine, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA. fergal.malone@es.nemc.org
Abstract
BACKGROUND: Reports suggest that perinatal infection with Brucella abortus does not cause poor obstetric outcomes, because of protective mechanisms in the human, not seen in animal species. CASE: We report a case of maternal brucellosis resulting in preterm labor, chorioamnionitis, placental abruption, and delivery of a live-born infant at 25 weeks' gestational age. Both maternal blood cultures and amniotic fluid cultures were positive for B abortus species, and delivery occurred despite aggressive antibiotic and tocolytic therapy. CONCLUSION: Maternal infection with B abortus during pregnancy can lead to significant perinatal morbidity, casting doubt on reports that human pregnancy is resistant to such infection.
BACKGROUND: Reports suggest that perinatal infection with Brucella abortus does not cause poor obstetric outcomes, because of protective mechanisms in the human, not seen in animal species. CASE: We report a case of maternal brucellosis resulting in preterm labor, chorioamnionitis, placental abruption, and delivery of a live-born infant at 25 weeks' gestational age. Both maternal blood cultures and amniotic fluid cultures were positive for B abortus species, and delivery occurred despite aggressive antibiotic and tocolytic therapy. CONCLUSION:Maternal infection with B abortus during pregnancy can lead to significant perinatal morbidity, casting doubt on reports that human pregnancy is resistant to such infection.
Authors: Angela M Arenas-Gamboa; Carlos A Rossetti; Sankar P Chaki; Daniel G Garcia-Gonzalez; Leslie G Adams; Thomas A Ficht Journal: Curr Trop Med Rep Date: 2016-10-01
Authors: Marit M A de Lange; Chantal W P M Hukkelhoven; Janna M Munster; Peter M Schneeberger; Wim van der Hoek Journal: BMJ Open Date: 2015-04-10 Impact factor: 2.692