Literature DB >> 11766882

Ebola virus: the search for vaccines and treatments.

J A Wilson1, C M Bosio, M K Hart.   

Abstract

Ebola viruses belong to the family Filoviridae, which are among the most virulent infectious agents known. These viruses cause acute, and frequently fatal, hemorrhagic fever in humans and nonhuman primates. Currently, no vaccines or treatments are available for human use. This review describes Ebola viruses, with a particular focus on the status of research efforts to develop vaccines and therapeutics and to identify the immune mechanisms of protection.

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Year:  2001        PMID： 11766882     DOI： 10.1007/PL00000821

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  17 in total

1.  Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana.

Authors:  Waranyoo Phoolcharoen; Seong H Bhoo; Huafang Lai; Julian Ma; Charles J Arntzen; Qiang Chen; Hugh S Mason
Journal:  Plant Biotechnol J       Date:  2011-02-01       Impact factor: 9.803

2.  Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates.

Authors:  Jason S Richardson; Stéphane Pillet; Alexander J Bello; Gary P Kobinger
Journal:  J Virol       Date:  2013-01-09       Impact factor: 5.103

3.  Protective cytotoxic T-cell responses induced by venezuelan equine encephalitis virus replicons expressing Ebola virus proteins.

Authors:  Gene G Olinger; Michael A Bailey; John M Dye; Russell Bakken; Ana Kuehne; John Kondig; Julie Wilson; Robert J Hogan; Mary Kate Hart
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

4.  Profiling the native specific human humoral immune response to Sudan Ebola virus strain Gulu by chemiluminescence enzyme-linked immunosorbent assay.

Authors:  Ariel Sobarzo; Eddie Perelman; Allison Groseth; Olga Dolnik; Stephan Becker; Julius Julian Lutwama; John M Dye; Victoria Yavelsky; Leslie Lobel; Robert S Marks
Journal:  Clin Vaccine Immunol       Date:  2012-09-19

5.  A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial.

Authors:  Julie E Martin; Nancy J Sullivan; Mary E Enama; Ingelise J Gordon; Mario Roederer; Richard A Koup; Robert T Bailer; Bimal K Chakrabarti; Michael A Bailey; Phillip L Gomez; Charla A Andrews; Zoe Moodie; Lin Gu; Judith A Stein; Gary J Nabel; Barney S Graham
Journal:  Clin Vaccine Immunol       Date:  2006-09-20

6.  Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs.

Authors:  Xiangguo Qiu; Gary Wong; Lisa Fernando; Jane Ennis; Jeffrey D Turner; Judie B Alimonti; Xiaojian Yao; Gary P Kobinger
Journal:  J Virol       Date:  2013-04-24       Impact factor: 5.103

7.  Ebola virus-like particles protect from lethal Ebola virus infection.

Authors:  Kelly L Warfield; Catharine M Bosio; Brent C Welcher; Emily M Deal; Mansour Mohamadzadeh; Alan Schmaljohn; M Javad Aman; Sina Bavari
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-12       Impact factor: 11.205

8.  Evaluation of Different Strategies for Post-Exposure Treatment of Ebola Virus Infection in Rodents.

Authors:  Jason S Richardson; Gary Wong; Stéphane Pillet; Samantha Schindle; Jane Ennis; Jeffrey Turner; James E Strong; Gary P Kobinger
Journal:  J Bioterror Biodef       Date:  2011-10-20

9.  The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

Authors:  Christopher F Basler; Andrea Mikulasova; Luis Martinez-Sobrido; Jason Paragas; Elke Mühlberger; Mike Bray; Hans-Dieter Klenk; Peter Palese; Adolfo García-Sastre
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

10.  Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine.

Authors:  Jason S Richardson; Michel K Yao; Kaylie N Tran; Maria A Croyle; James E Strong; Heinz Feldmann; Gary P Kobinger
Journal:  PLoS One       Date:  2009-04-23       Impact factor: 3.240
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