| Literature DB >> 11766734 |
J Fujimoto1, H Sakaguchi, I Aoki, H Toyoki, S Khatun, T Tamaya.
Abstract
Ginsenoside-Rb2 derived from ginseng inhibited invasiveness to the basement membrane of endometrial cancer cell lines Ishikawa. HHUA and HEC-1-A cells. These cells dominantly expressed matrix metalloproteinase (MMP)-2 (gelatinase A) among MMPs by zymography. Ginsenoside-Rb2 suppressed the expression and activity of MMP-2, but did not alter the expression of tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in the cells. Therefore, ginsenoside-Rb2 might inhibit invasiveness to the basement membrane via MMP-2 suppression in some endometrial cancers, and can be used as a medicine for inhibition of secondary spreading of uterine endometrial cancers.Entities:
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Year: 2001 PMID： 11766734
Source DB: PubMed Journal: Eur J Gynaecol Oncol ISSN： 0392-2936 Impact factor: 0.196