Literature DB >> 11765214

Drug transporters and their role in multidrug resistance of neoplastic cells.

J Kvackajová-Kisucká1, M Barancík, A Breier.   

Abstract

Multidrug resistance (MDR) of neoplastic cells, i.e. resistance towards large groups of unrelated drugs, represents the phenomenon that dramatically depresses the effectiveness of cancer chemotherapy. Membrane transport of ATPases from ABC superfamily plays an important role in MDR. In the present paper we are aiming to compare two members of this family: P-glycoprotein (PGP products of mdr genes) and multidrug resistance-associated protein (MRP, products of mrp genes) and their impact for MDR of neoplastic cells.

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Year:  2001        PMID： 11765214

Source DB:  PubMed          Journal:  Gen Physiol Biophys        ISSN： 0231-5882            Impact factor:   1.512


  6 in total

1.  Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-pi in human glioma.

Authors:  C Calatozzolo; M Gelati; E Ciusani; F L Sciacca; B Pollo; L Cajola; C Marras; A Silvani; L Vitellaro-Zuccarello; D Croci; A Boiardi; A Salmaggi
Journal:  J Neurooncol       Date:  2005-09       Impact factor: 4.130

2.  Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin.

Authors:  Refika I Pakunlu; Thomas J Cook; Tamara Minko
Journal:  Pharm Res       Date:  2003-03       Impact factor: 4.200

3.  Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

Authors:  Nagdeep Giri; Naveed Shaik; Guoyu Pan; Tetsuya Terasaki; Chisato Mukai; Shinji Kitagaki; Naoki Miyakoshi; William F Elmquist
Journal:  Drug Metab Dispos       Date:  2008-04-28       Impact factor: 3.922

4.  In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin.

Authors:  Bihter Atil; Evelyn Berger-Sieczkowski; Johanna Bardy; Martin Werner; Martin Hohenegger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-08-30       Impact factor: 3.000

5.  Ketone-selenoesters as potential anticancer and multidrug resistance modulation agents in 2D and 3D ovarian and breast cancer in vitro models.

Authors:  Simona Dobiasová; Nikoletta Szemerédi; Denisa Kučerová; Kamila Koucká; Radka Václavíková; Helena Gbelcová; Tomáš Ruml; Enrique Domínguez-Álvarez; Gabriella Spengler; Jitka Viktorová
Journal:  Sci Rep       Date:  2022-04-21       Impact factor: 4.996

Review 6.  Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors.

Authors:  Milan Hano; Lenka Tomášová; Mário Šereš; Lucia Pavlíková; Albert Breier; Zdena Sulová
Journal:  Molecules       Date:  2018-02-06       Impact factor: 4.411
  6 in total

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